Previous studies of supramolecular association through chalcogen-centred secondary bonding interactions (SBIs) demonstrated the versatility of 1,2,5-telluradiazoles and their annulated congeners, the benzo-2,1,3-telluradiazoles, as supramolecular building blocks. Key to the properties of those compounds is their propensity to undergo auto-association through the [Te-N]2 supramolecular synthon leading to dimers or supramolecular ribbon polymers. Moderate steric repulsion induces structural distortions of [Te-N]2 without dissociation and, in doing so, enables properties of practical interest such as chromotropism and second-order non-linear optical responses. However, moisture sensitivity discourages wide-spread application of these compounds. While being more tolerant of the atmosphere, the analogous selenadiazoles form weaker intermolecular interactions. Using a combined experimental and computational approach, this thesis investigates methods by which the selenium-centred supramolecular interactions can be enhanced and applied in the construction of supramolecular architectures.
The quantum mechanical description of the SBIs formed by 1,2,5-chalcogenadiazoles was updated with the application of modern dispersion corrections to relativistic density functional theory calculations (PBE-D3, ZORA). While in all cases the dispersion effect on optimized SBI distances is small (< 0.03 Å), the dispersion corrections to the calculated interaction energy range from 6 to 10 kJ mol-1 and increase with the weight of the chalcogen. The total interaction energy increases faster, however, therefore the relative weight of dispersion for the telluradiazole (10%) is significantly less than for the sulfur analogue (40%).
The same dispersion-corrected functional was applied to the identification of the secondary ions observed in the Laser Desorption Ionization mass spectrum of benzotelluradiazoles. The most stable structure of the [2M+H]+ ion was shown to feature the [Te-N]2 supramolecular synthon and would be preferred over alternatives held by hydrogen bonding alone, one TeN SBI, a combination of the two or -stacking. The [2M]+ would also feature the [Te-N]2 supramolecular synthon. Shortening of the TeN distances in these ions implies that electron withdrawing groups strengthen the SBIs.
The updated computational method was also applied to characterize the bonding in the adducts of a N-heterocyclic carbene with benzo-2,1,3-telluradiazole and 3,4-dicyano-2,1,5-telluradiazole recently prepared by the Zibarev group. The long TeC distances (2.53 and 2.34 Å) correspond to fractional bond orders (<0.6) but display a significant covalent character. Attachment of the carbene nearly erases the remaining σ-hole on tellurium, raises the LUMO energy and consequently prevents the dimerization of these adducts, in contrast to what has been observed with the pyridine and DMSO adducts of other telluradiazoles.
Benzo-2,1,3-selenenadiazole reacted with boranes (BR3, R = Ph, F, Cl, Br) yielding 1:1 (R = Ph, F, Cl, Br) and 1:2 (R = Cl) adducts. The crystal structure the BPh3 adduct features molecules organized in pairs connected by long SeC SBIs but no SeN SBIs. The BF3 and BCl3 1:1 adducts dimerize forming the [Se-N]2 supramolecular synthon. In contrast, the BBr3 adduct does not dimerize although SeBr, BrBr SBIs are formed through the lattice. The 1:2 adduct displays SeCl SBIs accompanied by distortion of the N-B-Cl bond angle due to the enhanced electrophilicity of the chalcogen. DFT calculations were performed to evaluate the energies of dimerization of the 1:1 adducts, the calculated SBI energies are greater than those for the dimer of the parent heterocycle (benzo-2,1,3-selenadiazole, 3b).
The products of the combination of benzo-2,1,3-selenenadiazole with chloride salts of divalent Mn, Fe, Co, Ni, and Cd crystallized from DMSO in two distinct structural types. While the smaller ions (FeII, CoII and NiII) form infinite chains of metal atoms N,N’-bridged by the heterocycle΄ the larger ions (MnII and CdII) stabilize infinite chains of metal atoms bridged by 2 halide ions. In the latter case, two heterocycle molecules cap each metal ion and are able to establish a link to the next chain in the lattice through the [Se‑N]2 supramolecular synthon. Despite the large (>9.2 Å) distance between [M(-Cl)2]∞ chains, the manganese derivative is only paramagnetic, not ferromagnetic. Symmetry-broken DFT calculations for small models were unable to quantitatively reproduce the measured couplings (J) but do indicate that the heterocycle acquires significant spin density in the MnII compound enabling paramagnetic coupling through the [Se‑N]2 supramolecular synthon.
General methods for the synthesis of N-alkylated selenadiazolium cations were investigated. Methyl, iso-propyl and tert-butyl benzo-2,1,3-selenadiazolium cations were prepared by direct alkylation or cyclo-condensation of the alkyl-phenylenediamine with selenous acid. While the former reaction only proceeds with the primary and tertiary alkyl iodides, the latter is very efficient. Difficulties reported in earlier literature are attributable to the formation of adducts of benzoselenadiazole with its alkylated cations and side reactions initiated by aerobic oxidation of iodide. However, the cations themselves are resilient to oxidation and stable in acidic to neutral aqueous media. X-ray crystallography was used in the identification and characterization of the following compounds: [C6H4N2(R)Se]+X-, (R = CH(CH3)2, C(CH3)3; X = I-, I3-), [C6H4N2(CH3)Se]+I-, and [C6H4N2Se][C6H4N2(CH3)Se]2I2. Formation of SeN SBIs was only observed in the last structure because anion binding to selenium is stronger. The relative strengths of those forces and the structural preferences they enforce were assessed with DFT-D3 calculations supplemented by AIM analyses of the electron density.
The methods developed for the preparation of N-alkyl benzoselenadiazolium cations were extended to the syntheses of dications intended for use as building blocks of supramolecular polymers. The structure of several salts was established by single-crystal X-ray diffraction. [H4C6NSeN-CH2-CH2-NSeNC6H4]Cl2 crystallized forming a macrocyclic structure in which two dications are bridged by SeCl SBIs; a third halide anion sits at the centre of the macrocycle. [1,2-(H4C6NSeN)2-C6H10]Cl2 features two selenadiazolium cations bridged by a 1‑(R),2‑(R)‑substituted cyclohexane and short SeCl SBIs. [1,4-(H4C6NSeN-CH2)2-C6H4](BF4)2, featuring a p-xylene bridge, crystallizes in two pseudopolymorphs; with dications in anti or syn conformations making SeF contacts. [H4C6NSeN-CH2-CH2-NSeNC6H4](CF3SO3)2 does dimerize though the [Se-N]2 supramolecular synthon, although SeO interactions with the anions cap the second selenium atom. In contrast, [H4C6NSeN-CH2-CH2-CH2-NSeNC6H4](CF3SO3)2 only displays SeO contacts.
An oligonucleotide analogue containing N-substituted selenadiazolium cations was designed to create foldamers with structures controlled by main-group secondary bonding. The target structures take advantage of the methods developed in this thesis for the functionalization of selenadiazoles and is meant to be compatible with automated methods for oligonucleotide synthesis. The proposed synthesis begins with the preparation of 1-(α,β)-O-methyl-2-deoxy-D-ribose, which was chlorinated and treated with phenylenediamine. High-resolution mass spectrometry confirmed the attachment of the diamine to the ribose, however, the yield was too low to continue this synthetic project.
A ground-breaking development in the application of secondary bonding in supramolecular chemistry is the discovery of the reversible auto-association of iso-tellurazole N-oxides through TeO SBIs into annular structures. These rings are persistent in solution and behave as actual macrocycles able to complex transition metal ions, form adducts with fullerenes, and host small molecules. Single-crystal X-ray diffraction was critical to the characterization of these structures and required careful disorder modelling for tetrahydrofuran molecules included in a macrocyclic hexamer and the occupational disorder of CH2Cl2 and BF4- anions due to metal depletion in the crystal of a PdII complex. / Thesis / Doctor of Philosophy (PhD) / Supramolecular chemistry is a prominent area of research that pursues the construction of large structures by the spontaneous assembly and organization of molecular building blocks. Its fundamental premise is that the judicious use of intermolecular forces allows the design of a structure and control of its properties. Most of the work in supramolecular chemistry has relied on hydrogen atoms bridging molecules and the bonding of metal ions to atoms rich in electrons. This thesis pursued the use of a different type of intermolecular force, termed “secondary bonding”, which is characteristic of the heaviest elements at the right of the periodic table (the “main-group” of elements).
Previous work at McMaster demonstrated that cyclic molecules containing carbon, nitrogen and tellurium were particularly efficient as supramolecular building blocks. However, they are easily degraded by atmospheric water, this fact severely limits practical applications of these compounds.
In this thesis, the tellurium atoms are replaced by selenium, a lighter element in the same family. The resulting molecules are more tolerant of atmospheric conditions but form weaker intermolecular links. Through a combination of quantum mechanical, synthetic, spectroscopic and structural studies, it is shown that certain modifications to the molecular structure increase the affinity of the selenium atoms for electrons. In this way, it is possible to strengthen the intermolecular interactions and promote the spontaneous assembly of supramolecular structures.
These investigations eminently fall in the category of fundamental research but have broad-reaching implications for practical applications in optical and electronic technologies.
Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/22115 |
Date | 11 1900 |
Creators | Lee, Lucia Myongwon |
Contributors | Vargas-Baca, Ignacio, Chemistry |
Source Sets | McMaster University |
Language | English |
Detected Language | English |
Type | Thesis |
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