The thesis evaluates three types of anhydrous β-lactose combined with lubri- cants. The evaluation is made from the standpoint of compressibilty, tensile strength and ejection force, depending on the compression force used. Studied materials are Duralac H, SuperTab 21AN and Lactopress Anhydrous 250. Lubricants used in the concentration of 1% are magnesium stearate, glycerol-dibehenate and poloxamer 188. Compressibility is evaluated by the energy profile of compression. Total energy of compression increases with compression force used and de- pends on the type of anhydrous β-lactose and type of lubricant. Higher plasticity is shown by Duralac H and SuperTab 21AN. Ejection force is lowest in the case of Duralac H for all lubricants. Magnesium stearate appears to be the best lubricant for all types of anhydrous β-lactose. The effect of lubricants on the tensile strength of tablets depends on the compression force used. Highest values of disintegration time provides SuperTab 21AN, Duralac H with glycerol-dibehenate provides lowest values. 1
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:332197 |
| Date | January 2014 |
| Creators | Foldyna, Edvard |
| Contributors | Mužíková, Jitka, Šklubalová, Zdeňka |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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