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APPLICATIONS OF ENANTIOPURE SULFINIMINE DERIVED CHIRAL AMINE BUILDING BLOCKS FOR THE ASYMMETRIC SYNTHESIS OF TROPANE ALKALOIDS AND CYCLIC CIS BETA-AMINO ACID DERIVATIVES

Chiral amines are ubiquitous in natural products and are found in many drugs and drug candidates. Enantiopure sulfinimines [RS(O)N=CHR1] are useful chiral building blocks for the stereoselective synthesis of amines and amine derivatives. The aim of this thesis research is to develop new methods to access chiral amine building blocks for applications in the synthesis of nitrogen-heterocycles including ring-substituted tropinones, tropanes, cyclic cis-beta-amino acid derivatives, and amino-cyclopentitols. / Chemistry

Identiferoai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/4111
Date January 2011
CreatorsTheddu, Naresh
ContributorsDavis, Franklin A., Andrade, Rodrigo B., Dalton, David R., 1936-, Cannon, Kevin C.
PublisherTemple University. Libraries
Source SetsTemple University
LanguageEnglish
Detected LanguageEnglish
TypeThesis/Dissertation, Text
Format238 pages
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Relationhttp://dx.doi.org/10.34944/dspace/4093, Theses and Dissertations

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