The thesis on the topic of the use of laboratory swine in biomedical research is focused on the detailed description of phylogeny and domestication of the species Sus scrofa and the origin of its domesticated form Sus scrofa domestica, a laboratory breeding, nutrition, requirements for space and the animal health conditions. Physiological and anatomical similarities pig with the human organism offers a wide range of the applications in various sectors of the medical research. Pigs, or rather the mini pig breeds are part of the preclinical testing of drugs in toxicology. In dermatology tend to be an experimental model in the healing wounds and burns, or the study of melanoma. Cardiovascular system of pigs is used in connection with the formation of atherosclerosis and congenital heart defects. The omnivorousness of pigs to test of dietary supplements; is also monitored in experimental diabetes, gastric ulcer or cirrhosis of the liver. Just the liver and their ability to regenerate them is in the laboratory pigs the focus of many research groups around the world. The central nervous system offers the opportunity to study stroke, or spinal cord injury. In transgenic animals is studied Huntington's disease and its treatment in humans. Titanium implants and various types of biomaterials are injected into the skeletal system of a pig, then reactions and bone healing are examined. In the area of experimental xenotransplantation could in the future be strains of genetically modified pigs become a source of organs for humans. While unresolved problem is the HAR-Hyperacute Rejection so rejection of the implant, and the risk of transmission of certain diseases from pigs to humans. Payoff experimental pigs is of undoubted importance and need this potential wisely and purposefully use, without wasting experimental animals and unnecessary pain. Emphasis should be placed on adherence to regulatory compliance and the concept of 3R.
Actual laboratory pigs breeding is at a high standard. Unfortunately, his major weakness on global scale is incomplete reported data related to exact values used pigs in experiments.
In the Czech Republic was the most laboratory pigs used in 1994 exactly 6882 pieces, in 1998 has been used 7122 pieces, higher number of laboratory swine was also reported for the year 2009, namely 4445 pieces. In recent years, the numbers of used laboratory pigs in the Czech Republic have settled around an average value of 2,400 pieces. Using the Mann-Whitney U test were compared to the values used in the laboratory pigs Czech Republic and the European Union, on a per capita basis. From the resulting value of p = 0.486, bigger than alpha = 0.05 it follows, that was not proved a difference in the use of experimental pigs between the Czech Republic and the other member states of the European Union. On the basis of the carried out statistical survey, it can be concluded that the fluctuations and trends in the use of laboratory pigs in the Czech Republic do not replicate those european. The established hypothesis was confirmed.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:258274 |
| Date | January 2016 |
| Creators | Šlajerová, Markéta |
| Contributors | Masopustová, Renata, Jan, Jan |
| Publisher | Česká zemědělská univerzita v Praze |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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