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Suzuki reactions in novel liquids

Non-ionic deep eutectic solvent (ni-DES) possesses various advantages such as good solvation, biodegradability, and non-toxicity which makes it a perfect and environmentally friendly solvent for organic synthesis. A Pd (OAc)2 catalyzed, Suzuki reaction of aryl bromide and N-heteroaryl halide with arylboronic acid in green and novel solvent (ni-DES) is described. In this work, the possibility of using ni-DES and the impact of this solvent on the scope of the reaction is studied. It is illustrated that using the mixture of N-alkyl derivatives of urea and acetamide as a green solvent for Suzuki reaction is achievable even though the desired amount of product was not obtained. However, the high yield in ni-DES can be obtained by choosing 4-bromobenzotrifluoride or 4-bromoanisole as the aryl bromide with arylboronic acid that possess the electron donating groups. Despite that, for getting more yield through Suzuki reaction in ni-DES more studies on optimization are required.

Identiferoai:union.ndltd.org:UPSALLA1/oai:DiVA.org:lnu-106739
Date January 2021
CreatorsHassanzadeh, Nazanin
PublisherLinnéuniversitetet, Institutionen för kemi och biomedicin (KOB)
Source SetsDiVA Archive at Upsalla University
LanguageEnglish
Detected LanguageEnglish
TypeStudent thesis, info:eu-repo/semantics/bachelorThesis, text
Formatapplication/pdf
Rightsinfo:eu-repo/semantics/openAccess

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