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Angioedema: A Life-threatening Complication of Tissue Plasminogen Activator

Angioedema is a localized, non-pitting, non-dependent, submucosal, and subcutaneous swelling resulting from the extravasation of fluid into the interstitium due to the increased production of plasma kinins and histamine. It can present with urticaria or anaphylaxis and is usually associated with angiotensin-converting enzyme inhibitors (ACEis), complement deficiencies, or the side effects of tissue plasminogen activator (tPA). Orolingual angioedema following tPA for acute ischemic stroke is a transient, self-resolving hemifacial swelling contralateral to neurological deficits that can rarely progress to the airway, compromising it and leading to a life-threatening situation if not managed promptly.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-2-1191
Date29 March 2018
CreatorsKhalid, Muhammad, Kanaa, Majd, Alkawaleet, Yazan, Ayub, Muhammad T.
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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