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Tubulin in vitro, in vivo and in silico

Tubulin, microtubules and associated proteins were studied theoretically, computationally and experimentally in vitro and in vivo in order to elucidate the possible role these play in cellular information processing and storage. Use of the electric dipole moment of tubulin as the basis for binary switches (biobits) in nanofabricated circuits was explored with surface plasmon resonance, refractometry and dielectric spectroscopy. The effects of burdening the microtubular cytoskeleton of olfactory associative memory neurons with excess microtubule associated protein TAU in Drosophila fruitflies were determined. To investigate whether tubulin may be used as the substrate for quantum computation as a bioqubit, suggestions for experimental detection of quantum coherence and entanglement among tubulin electric dipole moment states were developed.

Identiferoai:union.ndltd.org:TEXASAandM/oai:repository.tamu.edu:1969.1/1635
Date17 February 2005
CreatorsMershin, Andreas
ContributorsNanopoulos, Dimitri V., Kattawar, George W., Schuessler, Hans A., Zoran, Mark J.
PublisherTexas A&M University
Source SetsTexas A and M University
Languageen_US
Detected LanguageEnglish
TypeElectronic Dissertation, text
Format1769122 bytes, electronic, application/pdf, born digital

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