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The impact of iron-sulfur assembly on the mitochondrial tRNA import in \kur{Trypanosoma brucei} / The impact of iron-sulfur assembly on the mitochondrial tRNA import in \kur{Trypanosoma brucei}

This thesis addresses several aspects of mitochondrial iron sulfur (Fe-S) cluster biogenesis and mitochondrial tRNA import and modifications in Trypanosoma brucei. Using RNA interference it uncovers essential role of Fe-S cluster assembly in tRNA(s) thiolation in both the cytosol and the mitochondrion of T. brucei. Further, this thesis describes the role of modifications in tRNA editing and in mitochondrial import of tRNAs. Finally, it provides evidence that in contrast to protein import, mitochondrial membrane potential is dispensable for import of tRNAs into the mitochondrion of T. brucei.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:54133
Date January 2010
CreatorsPARIS, Zdeněk
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/doctoralThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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