In this thesis focused ultrasound thrombolysis was investigated in vitro and in vivo. At high intensities it was demonstrated that clot breakdown only arises under the presence of inertial cavitation for longer pulse lengths, consistent with observations at significantly shorter pulse durations, and that the majority of clot debris is sub-capillary in size. Evidence of flow restoration was demonstrated in vivo by partially restoring flow to an occluded rabbit femoral artery. At slightly lower intensities it was observed that steady- state clot displacements scale linearly with power for clots treated with focused ultrasound pulses, and in some cases can reach magnitudes up to several hundred microns. It was demonstrated that the shear strain exerted on the clot by a focused ultrasound pulse scale with power, which may be implicated in enhancing drug permeation for studies in combination with lytic agents.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/25522 |
| Date | 30 December 2010 |
| Creators | Wright, Cameron |
| Contributors | Goertz, David |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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