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Inhibition of Toll-Like Receptor 9 Attenuates Sepsis-Induced Mortality Through Suppressing Excessive Inflammatory Response

Sepsis, a major clinical problem with high morbidity and mortality, is caused by overwhelming systemic host-inflammatory response. Toll-like receptors (TLRs) play a fundamental role in induction of hyperinflammation and tissue damage in sepsis. In this study, we demonstrate a protective role of TLR9 inhibition against the dysregulated inflammatory response and tissue injury in sepsis. TLR9 deficiency decreased the mortality of mice following cecal ligation and puncture (CLP)-induced sepsis. TLR9 knockout mice showed dampened p38 activation and augmented Akt phosphorylation in the spleen, lung and liver. In addition, TLR9 deficiency decreased the levels of inflammatory cytokines and attenuated splenic apoptosis after CLP. These results indicate that TLR9 inhibition might offer a novel therapeutic strategy for the management of sepsis.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-16695
Date01 June 2015
CreatorsHu, Dan, Yang, Xiaohua, Xiang, Yanxiao, Li, Hui, Yan, Hui, Zhou, Jun, Caudle, Yi, Zhang, Xiumei, Yin, Deling
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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