Although the drug-eluting stent (DES) has dramatically reduced the rate of coronary restenosis, it still occurs in up to 20% of patients with a DES. Monitoring drug delivery could be one way to decrease restenosis rates. We demonstrate real-time photoacoustic imaging and spectroscopy (PAIS) using a wavelength-tunable visible laser and clinical ultrasound scanner to track cardiac drug delivery. The photoacoustic signal was initially calibrated using porcine myocardial samples soaked with a known concentration of a drug surrogate (Dil). Next, an in situ coronary artery was perfused with DiI for 20 min and imaged to monitor dye transport in the tissue. Finally, a partially DiI-coated stent was inserted into the porcine brachiocephalic trunk for imaging. The photoacoustic signal was proportional to the DiI concentration between 2.4 and 120 mu g/ml, and the dye was detected over 1.5 mm from the targeted coronary vessel. Photoacoustic imaging was also able to differentiate the DiI-coated portion of the stent from the uncoated region. These results suggest that PAIS can track drug delivery to cardiac tissue and detect drugs loaded onto a stent with sub-mm precision. Future work using PAIS may help improve DES design and reduce the probability of restenosis. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/624370 |
| Date | 13 February 2017 |
| Creators | Furdella, Kenneth J., Witte, Russell S., Vande Geest, Jonathan P. |
| Contributors | Univ Arizona, Dept Med Imaging, University of Pittsburgh, Department of Bioengineering, Pittsburgh, Pennsylvania, United States, University of Arizona, Department of Medical Imaging, Tucson, Arizona, United States, University of Pittsburgh, Department of Bioengineering, Pittsburgh, Pennsylvania, United States |
| Publisher | SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS |
| Source Sets | University of Arizona |
| Language | English |
| Detected Language | English |
| Type | Article |
| Rights | © 2017 Society of Photo-Optical Instrumentation Engineers |
| Relation | http://biomedicaloptics.spiedigitallibrary.org/article.aspx?doi=10.1117/1.JBO.22.4.041016 |
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