Return to search

A role for transforming growth factor alpha and its receptor in human oesophageal cancer

A dissertation submitted to the Faculty of Science, University of the
Witwatersrand, Johannesburg, in fulfilment of the requirements for the
degree of Master of Science. / A member of the epidermal growth factor (EGF) family; transforming
growth factor alpha (TGF-a) shares significant homology with EGF and
binds to the EGF receptor (EGF-R). Like EGF TGF-a plays important
roles in normal physiological processes; but, as its name signifies, it has
potent transforming ability; often associated with autocrine stimulatory
mechanisms. The purpose of this study is to investigate a possible role
for TGF-a and its receptor in certam human oesophageal squamous cell
carcinoma (SCC) cell lines - namely, WHCO-I, -3 and -5. The wellstudied
A431 epidermoid. carcinoma cell line was used throughout for
control purposes. (Abbreviation abstract) / Andrew Chakane 2018

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/25852
Date January 1993
CreatorsJones, Gregory Justin
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
TypeThesis
Formatapplication/pdf

Page generated in 0.0018 seconds