Levels of soybean trypsin inhibitors (SBTI) in soy-based infant formulas were measured and found to range from 3 to 28% of the activity measured in raw soybeans, with higher activity usually present in ready-to-feed compared to concentrate or powder formulations. Experiments were conducted to examine the influence of dietary SBTI on growth, serum enzyme, lipid and free amino acids and hepatic S-adenosylmethionine (SAM) status in weanling male rats. Diets containing graded amounts of SBTI were fed with and without the methionine antagonist ethionine. Changes in growth, serum enzymes, lipid and amino acid parameters in rats fed SBTI or ethionine indicated lipotrope deficit and compromise of the transsulfuration pathway. The combination of SBTI and ethionine exacerbated many of the symptoms and methyl donor deficit was indicated by hepatic SAM status. Methionine supplementation of SBTI + ethionine diets was beneficial at moderating changes while cysteine supplementation was not.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.74606 |
| Date | January 1991 |
| Creators | Peace, Robert William |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Animal Science.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001222369, proquestno: AAINN67607, Theses scanned by UMI/ProQuest. |
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