Yes / Aggregating and forming biofilms on biotic or abiotic surfaces are ubiquitous bacterial
behaviors under various conditions. In clinical settings, persistent presence of biofilms
increases the risks of healthcare-associated infections and imposes huge healthcare
and economic burdens. Bacteria within biofilms are protected from external damage
and attacks from the host immune system and can exchange genomic information
including antibiotic-resistance genes. Dispersed bacterial cells from attached biofilms
on medical devices or host tissues may also serve as the origin of further infections.
Understanding how bacteria develop biofilms is pertinent to tackle biofilm-associated
infections and transmission. Biofilms have been suggested as a continuum of growth
modes for adapting to different environments, initiating from bacterial cells sensing their
attachment to a surface and then switching cellular physiological status for mature
biofilm development. It is crucial to understand bacterial gene regulatory networks
and decision-making processes for biofilm formation upon initial surface attachment.
Pseudomonas aeruginosa is one of the model microorganisms for studying bacterial
population behaviors. Several hypotheses and studies have suggested that extracellular
macromolecules and appendages play important roles in bacterial responses to the
surface attachment. Here, I review recent studies on potential molecular mechanisms
and signal transduction pathways for P. aeruginosa surface sensing. / This work is supported by University of Bradford
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/15205 |
| Date | 01 September 2018 |
| Creators | Chang, Chien-Yi |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | © 2018 Chang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms., CC-BY |
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