by Lai Wing Hong Kevin. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1995. / Includes bibliographical references (leaves 63-74). / Acknowledgments --- p.i / Abbreviations --- p.ii / Abstract --- p.1 / Chapter Chapter 1 --- General Introduction --- p.3 / Chapter 1.1 --- Advantages of Antisense Oligonucleotides Inhibition --- p.4 / Chapter 1.2 --- The Uses of Antisense Oligonucleotide in Leukemic Therapy --- p.5 / Chapter 1.3 --- Oncogenes in the Pathogenesis of Leukemia --- p.6 / Chapter 1.4 --- Apoptosis and Apoptosis-Related Genes --- p.9 / Chapter 1.5 --- Protooncogene bcl-2 --- p.10 / Chapter 1.6 --- Bcl-2 Homologues --- p.11 / Chapter 1.7 --- Regulation of Apoptosis by Other Genes --- p.13 / Chapter 1.8 --- Promyelocytic Leukemia HL-60 Cell Line --- p.15 / Chapter 1.9 --- Aim of Project --- p.16 / Chapter Chapter 2 --- Chemical Synthesis of DNA Oligonucleotides / Chapter 2.1 --- Introduction --- p.17 / Chapter 2.2 --- Materials and Methods --- p.20 / Chapter 2.3 --- Results --- p.24 / Chapter 2.4 --- Discussion --- p.26 / Chapter Chapter 3 --- The Apoptotic Effects of TPA and Ouabain on the Promyelocytic Leukemic HL-60 cell line / Chapter 3.1 --- Introduction --- p.30 / Chapter 3.2 --- Materials and methods --- p.33 / Chapter 3.3 --- Results --- p.40 / Chapter 3.4 --- Discussion --- p.44 / Chapter Chapter 4 --- Effect of Antisense Oligonucleotides on TPA-Induced Apoptosisin Leukemic HL-60 cells / Chapter 4.1 --- Introduction --- p.48 / Chapter 4.2 --- Materials and Methods --- p.49 / Chapter 4.3 --- Results --- p.52 / Chapter 4.4 --- Discussion --- p.54 / Chapter Chapter 5 --- General Discussion --- p.57 / References --- p.63
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_320716 |
| Date | January 1995 |
| Contributors | Lai, Wing Hong Kevin., Chinese University of Hong Kong Graduate School. Division of Basic Medical Sciences. |
| Publisher | Chinese University of Hong Kong |
| Source Sets | The Chinese University of Hong Kong |
| Language | English |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, ii, 74 leaves, [46] leaves of plates : ill. (some mounted col.) ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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