HIV represents a global health problem. The phenomenon of HIV latency presents challenges in treating and curing HIV infection. Understanding the mechanisms behind HIV latency may provide the route to cure HIV. In a subset of elite controllers, elevated levels of p21 provide resistance to HIV replication by inhibiting transcription. I attempted to understand the mechanisms by overexpressing p21 in HEK 293T cells.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/13978 |
| Date | 03 November 2015 |
| Creators | Chapman, Blake Edward |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
| Rights | Attribution-ShareAlike 4.0 International, http://creativecommons.org/licenses/by-sa/4.0 |
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