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Identification and quantitation of urinary methylmalonic acid by gas chromatography - Mass fragmentography.

by Lai Wai Kai. / Thesis (M.Sc.)--Chinese University of Hong Kong, 1996. / Includes bibliographical references (leaves 70-74). / Acknowledgement --- p.iv / Abstract --- p.v / Figures and Tables --- p.vii / Abbreviations used in this study --- p.ix / Contents / Chapter 1. --- Introduction --- p.1 / Chapter 1.1 --- Biochemistry of cobalamin --- p.2 / Chapter 1.1.1 --- Biological functions of cobalamin --- p.2 / Chapter 1.1.2 --- Causes of cobalamin deficiency --- p.4 / Chapter 1.1.3 --- Significances of cobalamin deficiency --- p.7 / Chapter 1.1.4 --- Assessment of cobalamin deficiency --- p.8 / Chapter 1.2 --- Biochemistry of Methylmalonic acid (MMA) --- p.10 / Chapter 1.2.1 --- Elevation of MMA in biological fluids --- p.11 / Chapter 1.2.2 --- Significances of measurement of MMA --- p.11 / Chapter 1.2.3 --- Methods of measurement of urinary MMA --- p.13 / Chapter 2. --- Objectives of this project --- p.16 / Chapter 3. --- Materials and Methods / Chapter 3.1 --- Study subjects --- p.18 / Chapter 3.2 --- Sample collection --- p.18 / Chapter 3.3 --- Biochemical and haematological analysis --- p.18 / Chapter 3.4 --- Measurement of urinary creatinine concentration --- p.19 / Chapter 3.5 --- Measurement of serum cobalamin concentration --- p.20. / Chapter 3.6 --- GC-MS determination of urinary MMA --- p.21 / Chapter 3.7 --- Statistical analysis --- p.24 / Chapter 4. --- Results / Chapter 4.1 --- Clinical features of subjects --- p.28 / Chapter 4.2 --- General blood analysis --- p.28 / Chapter 4.3 --- Serum cobalamin analysis --- p.30 / Chapter 4.4 --- Urinary MMA analysis --- p.33 / Chapter 4.5 --- Relationship between urinary MMA excretion and age --- p.53 / Chapter 4.6 --- Relationship between urinary MMA excretion and serum cobalamin concentrations --- p.53 / Chapter 5. --- Discussions / Chapter 5.1 --- Serum cobalamin analysis --- p.62 / Chapter 5.2 --- Urinary MMA analysis --- p.62 / Chapter 5.3 --- Relationship between urinary MMA excretion and age --- p.66 / Chapter 5.4 --- Relationship between urinary MMA excretion and serum cobalamin concentration --- p.66 / Chapter 5.5 --- Relationship between urinary MMA excretion and diet --- p.68 / Chapter 6. --- Conclusions --- p.69 / Chapter 7. --- References --- p.70

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_321662
Date January 1996
ContributorsLai, Wai Kai., Chinese University of Hong Kong Graduate School. Division of Clinical Biochemistry.
PublisherChinese University of Hong Kong
Source SetsThe Chinese University of Hong Kong
LanguageEnglish
Detected LanguageEnglish
TypeText, bibliography
Formatprint, ix, 74 leaves : ill. ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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