B vitamins are of interest in preventative and protective strategies in cardiovascular disease. However, the safety and efficacy of B vitamins has been questioned. Previous research from this group has demonstrated that B6 supplementation alone or in combination with folic acid and B12 reduces angiogenic response. This study determined the effect of vitamin B6 deficiency on the angiogenic response after ischemia in vivo and in vitro using a rodent model. Results indicated that vitamin B6 deficiency enhanced the early angiogenic response by increasing blood flow in vivo after an ischemic event. In vitro measurements demonstrated that vitamin B6 deficiency influenced endothelial progenitor cell (EPC) function and angiogenic growth factor release early after ischemia. In conclusion, B6 deficiency appears to have a modest effect on increasing blood flow and angiogenic markers after ischemia. Additional research is needed to further characterize the impact of lowered vitamin B6 on angiogenesis and its mechanisms.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33605 |
| Date | 27 November 2012 |
| Creators | Yuen, Nicole |
| Contributors | Keith, Mary E. |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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