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Action of pungent and non-pungent vanilloids on the emetic reflex and mechanisms modulating temperature and grooming in Suncus murinus.

Wan Pui Chu Christina. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (leaves 167-191). / Abstracts in English and Chinese. / PUBLICATIONS BASED ON WORK IN THIS THESIS --- p.i / ABSTRACT --- p.ii / ACKNOWLEDGEMENT --- p.vii / TABLE OF CONTENTS --- p.viii / Chapter CHAPTER 1 --- INTRODUCTION --- p.1 / Chapter 1.1 --- Introduction to the Vanilloid Receptor --- p.1 / Chapter 1.1.1 --- Properties of the VR1 Channel --- p.2 / Chapter 1.1.2 --- Explaining the Unexplained: De sensitization and Pungency --- p.6 / Chapter 1.2 --- The Quest for the Endogenous Ligand: Activation versus Modulation --- p.2 / Chapter 1.2.1 --- Anandamide and the Cannabinoid System --- p.12 / Chapter 1.2.2 --- Inflammatory Mediators and Lipid Metabolites --- p.15 / Chapter 1.3 --- The Variegated Vanilloid Receptor: Multiple Actions of TRPV1 --- p.18 / Chapter 1.3.1 --- Vanilloid-induced Hypothermia: some like it cold --- p.18 / Chapter 1.3.2 --- "Three's a crowd: Vanilloids, Substance P, and the Emetic Reflex" --- p.22 / Chapter 1.3.3 --- Grooming Behavior and Locomotor Changes: Further Involvement of Neurokinins? --- p.29 / Chapter 1.4 --- Aims and Objectives of the Present Study --- p.33 / Chapter CHAPTER 2 --- METHODS --- p.39 / Chapter 2.1 --- Animals --- p.39 / Chapter 2.2 --- Stereotaxic Surgery and Transmitter Implantation --- p.39 / Chapter 2.3 --- Measurement of Emesis and Genital Grooming --- p.41 / Chapter 2.4 --- Measurement of Locomotor Activity and Body Temperature --- p.41 / Chapter 2.5 --- Experimental Procedures for Central Injection Studies --- p.45 / Chapter 2.6 --- Experimental Procedures for Peripheral Injection Studies --- p.47 / Chapter 2.7 --- Drug Formulation --- p.48 / Chapter 2.8 --- Statistical Analysis --- p.49 / Chapter CHAPTER 3 --- RESULTS --- p.51 / Chapter 3.1 --- Actions of Intracerebroventricularly Administered Vanilloid Agonists --- p.51 / Chapter 3.1.1 --- General Behaviour --- p.51 / Chapter 3.1.2 --- Emetic Action of Vanilloids --- p.52 / Chapter 3.1.3 --- Anti-Emetic action of Vanilloids against Copper Sulphate --- p.55 / Chapter 3.1.4 --- Vanilloid-induced Hypothermia --- p.58 / Chapter 3.1.5 --- RTX-induced Genital Grooming --- p.65 / Chapter 3.1.6 --- Effects of Vanilloids on Locomotor Activity --- p.67 / Chapter 3.1.7 --- Summary of Central Agonist Studies --- p.76 / Chapter 3.2 --- Effects of Intracerebroventricularly Administered Capsazepine on Vanilloid-induced Responses --- p.78 / Chapter 3.2.1 --- Effect of Capsazepine on Vanilloid-induced Emesis --- p.78 / Chapter 3.2.2 --- Effect of Capsazepine on the Anti-Emetic Action of Vanilloids --- p.82 / Chapter 3.2.3 --- Effect of Capsazepine on Vanilloid-induced Hypothermia --- p.84 / Chapter 3.2.4 --- Effect of Capsazepine on RTX-induced Genital Grooming --- p.88 / Chapter 3.2.5 --- Effect of Capsazepine on Locomotor Activity of Vanilloid-treated Animals --- p.90 / Chapter 3.3 --- "Peripheral Studies with RTX,,Capsazepine, and Ruthenium Red" --- p.93 / Chapter 3.1.1 --- Experiment 1: Actions of Resiniferatoxin --- p.93 / Chapter 3.1.2 --- Experiment 2: Effects of Capsazepine and Ruthenium Red administered alone --- p.99 / Chapter 3.1.3 --- Experiment 3: Effects of Capsazepine and Ruthenium Red on RTX- induced Responses --- p.104 / Chapter CHAPTER 4 --- DISCUSSION --- p.113 / Chapter 4.1 --- General Considerations --- p.113 / Chapter 4.2 --- Emetic Action of Vanilloids --- p.116 / Chapter 4.3 --- Anti-Emetic Action of Vanilloids --- p.124 / Chapter 4.4 --- Hypothermic Action of Vanilloids --- p.133 / Chapter 4.5 --- Resiniferatoxin-induced Genital Grooming --- p.147 / Chapter 4.6 --- Actions of Capsazepine and Ruthenium Red --- p.152 / Chapter 4.7 --- Locomotor Activity --- p.157 / Chapter CHAPTER 5 --- SUMMARY --- p.162 / REFERENCES --- p.167

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_324907
Date January 2004
ContributorsWan, Pui Chu Christina., Chinese University of Hong Kong Graduate School. Division of Pharmacology.
Source SetsThe Chinese University of Hong Kong
LanguageEnglish, Chinese
Detected LanguageEnglish
TypeText, bibliography
Formatprint, x, 191 leaves : ill. ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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