Previous studies of the grey wolf (Canis lupus) using microsatellites have showed strong population structure despite the high mobility of individuals. I re-assessed the structure of North American grey wolves by genotyping 132 wolves at a genome-wide set of >26 000 single nucleotide polymorphisms (SNPs), and found less population structure, a strong pattern of isolation by distance, and determined that gene flow between subpopulations relates to prey specialization. To assess how accurately smaller data sets assign individuals, I analyzed sub-sets of SNPs and found that small marker sets varied greatly in estimates of subpopulation assignment, and showed high discordance with assignments determined when using all 26k markers. Finally, using a genome scan to detect natural selection I identified SNPs in three genes that may have undergone directional selection, contain variation with observed phenotypic consequences in other mammal species and may be related to adaptation in grey wolves. / Systematics and Evolution
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:AEU.10048/1237 |
| Date | 11 1900 |
| Creators | Knowles, James |
| Contributors | Coltman, David (Biological Sciences), Hall, Jocelyn (Biological Sciences), Moore, Stephen (Agricultural, Food and Nutritional Science) |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 2153751 bytes, application/pdf |
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