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Autophagic degradation of peroxisomes in the alkane-assimilating yeast Yarrowia lipolytica / Autophagischer Abbau von Peroxisomen in der alkanverwertenden Hefe Yarrowia lipolytica

The thesis is aimed at understanding of molecular mechanisms of autophagic degradation of peroxisomes (pexophagy) in the yeast Yarrowia lipolytica. This microorganism has been extensively used to explore peroxisome biogenesis (Titorenko and Rachubinski, 2000). Gunkel et al. (1999) intoduced Y. lypolitica into pexophagy studies. However, the field of pexophagic research on this yeast remains quite unexplored. This work involved following tasks: (1) the development and optimization of Y. lipolytica as a model system to study peroxisome degradation; (2) Y. lipolytica genes and proteins implicated in pexophagy should be found and characterized; (3) a proper easy-to-handle selection procedure to isolate novel peroxisome degradation-deficient(pdd) mutants of Y. lipolytica should be devised.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa.de:swb:14-1164836301920-35300
Date02 December 2006
CreatorsParshyna, Iryna
ContributorsTechnische Universität Dresden, Biologie, Technische Universität Dresden, Institut für Mikrobiologie, Prof. Dr. rer. nat. Gerold Barth, Prof. Dr. rer. nat. Marten Veenhuis, Prof. Dr. rer. nat. Gerold Barth, Prof. Dr. Richard Rachubinski
PublisherSaechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typedoc-type:doctoralThesis
Formatapplication/pdf

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