Separations depend on the molecular interactions occurring on retentive surfaces. Much time and effort is paid in the design and manufacture of chromatographic surfaces that enhance separation capability. This thesis explores some of the design concepts currently available in the market place, and while doing so, investigates the mode of retention on a range of solute species. The information gained from the investigation of the retention and thermodynamic retention behaviour of stationary phases, along with molecular modelling carried out on their stationary phase ligand conformation assists in the design of stationary phase materials that enhance separations. Results from this study indicate that the aromatic functionality on the Synergi-polar-RP column may be diminished, due to the orientation of the phenyl ring on the stationary phase surface. / Doctor of Philosophy (PhD)
| Identifer | oai:union.ndltd.org:ADTP/189133 |
| Date | January 2005 |
| Creators | Kayillo, Sindy, University of Western Sydney, College of Science, Technology and Environment, School of Science, Food and Horticulture |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
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