Includes bibliographical references. / 146, [65] leaves, [18] leaves of plates : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / The major aim of this thesis is to establish whether toxin-coregulated pilus (TCP) is significant in the pathogenesis of Vibrio cholerae strains of the alternative El Tor biotype. The study investigates whether TCP are assembled by El Tor strains during growth in vitro, evaluates the in vivo significance of TCP by constructing tcpA mutants of several El Tor strains and comparing their in vivo behaviour with wild-type and determines whether the TCP produced by the 017 cosmid clones is solely cosmid-derived or whether the chromosomal tcp operon is also expressed. / Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1996
| Identifer | oai:union.ndltd.org:ADTP/259868 |
| Date | January 1995 |
| Creators | Voss, Elena |
| Source Sets | Australiasian Digital Theses Program |
| Language | en_US |
| Detected Language | English |
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