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An in vivo and in vitro characterisation study of endothelin-1 and its receptors in tumour-associated endothelial cells.

Endothelin-1 (ET-1) is a potent vasoactive peptide, cleaved from its inactive precursor, big ET-1, by Endothelial Converting Enzyme-1 (ECE-1). ET-1 normally regulates vascular tone via its two receptors ET-A and ET-B. As ET-1 is found to be over-expressed in many tumour models, it has been implicated as having a role in neovascularisation. / Thesis (PhDBiomedicalScience)--University of South Australia, 2005.

Identiferoai:union.ndltd.org:ADTP/267171
CreatorsCaruso, Maria Concetta.
Source SetsAustraliasian Digital Theses Program
LanguageEnglish
Detected LanguageEnglish
Rightscopyright under review

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