The global threat from antibiotic resistant organisms and the effect on human and animal health is now well acknowledged. One measure to control the emergence and dissemination of antibiotic resistant organisms is to monitor bacterial populations and examine the epidemiology of antibiotic resistance genes in naturally occurring bacteria. This study examines antibiotic resistant bacteria of human and animal origin and compares resistance gene transfer in the intestinal tract of animal models to that which occurs in vitro. / The study provides information about tetracycline resistance as it occurs in wild-type bacteria within the environment of the normal flora of an animal. The transfer of tetracycline resistance genes in vitro between E. coli isolates from different origins was found to be occurring at lower levels than that which occurred in vitro. The co-transfer of unselected spectinomycin, streptomycin and sulfadiazine resistance in animal models was also demonstrated. / The study has provided important information regarding the nature and epidemiology of antibiotic resistance in naturally occurring strains of E. coli and enterococci from Australia. This should form part of a larger study, which monitors commensal bacteria and collects data regarding antibiotic resistance in natural populations of bacteria. This evidence can then be used to reduce the levels of antibiotic resistance in the environment and reduce the risk to human and animal health. / Thesis (PhD)--University of South Australia, 2006.
| Identifer | oai:union.ndltd.org:ADTP/267284 |
| Date | January 2006 |
| Creators | Hart, Wendy S. |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
| Rights | copyright under review |
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