Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / Mucositis is a common side-effect of chemotherapy, which is characterised by ulceration to the epithelium lining of the gastrointestinal tract. Recently, a non-invasive breath test, the ¹³C-sucrose breath test (SBT), has been developed and applied as a biomarker to detect small intestinal damage associated with methotexate (MTX)-induced mucositis in rats. This thesis extended this work, and concluded that the non-invasive SBT is a biomarker of small intestinal function that can be applied easily and cost-effectively, in both animals and humans, to monitor gut function in relation to chemotherapy agents and/or potential anti-mucositis treatments. This thesis has illustrated the important application of the SBT in the arena of supportive cancer care, where new chemotherapy and anti-mucositis agents can be assessed in relation to small intestinal toxicity. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1277572 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2007
| Identifer | oai:union.ndltd.org:ADTP/272841 |
| Date | January 2007 |
| Creators | Tooley, Katie Louise |
| Source Sets | Australiasian Digital Theses Program |
| Detected Language | English |
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