Increasing elastin fibre production in a tissue engineered mesh for pelvic floor surgery

Description

yes / Polypropylene mesh for pelvic floor surgery is associated with serious complications ( e.g. erosion). A biodegradable tissue engineered mesh composed of a polylactic acid (PLA) scaffold seeded with autologous cells is a promising alternative.
However, thus far elastin content (important for elastic recoil) in this tissue has been low. We aimed to increase elastin expression and test the resultant tensile properties.

Links & Downloads

1. Osman I, Roman S, Sefat F, Bullock AJ and Chapple CR (2014) Increasing elastin fibre production in a tissue engineered mesh for pelvic floor surgery. European Urology Supplements. 13(1): 483.
2. http://hdl.handle.net/10454/11154
3. https://doi.org/10.1016/S1569-9056(14)60476-0

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Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11154
Date	January 2014
Creators	Osman, N., Roman, S., Sefat, Farshid, Bullock, A.J., Chapple, C.R.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, Accepted Manuscript
Rights	© 2014 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.