Yes / PURPOSE. To compare microperimetric sensitivity around the monocular preferred retinal
locus (mPRL) in age-related macular degeneration (AMD) to normative data, and to describe
the characteristics of visual field defects around the mPRL in AMD.
METHODS. Participants with AMD (total n ¼ 185) were either prospectively recruited (n ¼
135) or retrospectively reviewed from an existing database (n ¼ 50). Participants underwent
microperimetry using a test pattern (37 point, 58 radius) centered on their mPRL. Sensitivities
were compared to normative data by spatial interpolation, and conventional perimetric
indices were calculated. The location of the mPRL relative to the fovea and to visual field
defects was also investigated.
RESULTS. Location of mPRL varied approximately 158 horizontally and vertically. Visual field
loss within 58 of the mPRL was considerable in the majority of participants (median mean
deviation 14.7 dB, interquartile range [IQR] 19.6 to 9.6 dB, median pattern standard
deviation 7.1 dB [IQR 4.8–9.0 dB]). Over 95% of participants had mean total deviation worse
than 2 dB across all tested locations and similarly within 18 of their mPRL. A common
pattern of placing the mPRL just foveal to a region of normal pattern deviation was found in
78% of participants. Total deviation was outside normal limits in this region in 68%.
CONCLUSIONS. Despite altering fixation to improve vision, people with AMD exhibit
considerable visual field loss at and around their mPRL. The location of the mPRL was
typically just foveal to, but not within, a region of relatively normal sensitivity for the
individual, suggesting that a combination of factors drives mPRL selection. / This report presents independent research funded by the NIHR
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/12116 |
| Date | 05 1900 |
| Creators | Denniss, Jonathan, Baggaley, H.C., Brown, G.M., Rubin, G.S., Astle, A.T. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | Copyright 2017 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. |
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