Continuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency

Description

Yes / Chemical manufacturing typically requires more than one step,
involving multiple batch processes, which makes synthesis at scale
laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be
carried out as a continuous multi-component reaction (MCR), by
twin screw extrusion (TSE), in the complete absence of solvent. / EPSRC (EP/L019655/1).

Links & Downloads

1. Crawford DE, Miskimmin CK, Cahir J et al (2017) Continuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency. Chemical Communications. 53(97): 13067-13070.
2. http://hdl.handle.net/10454/17693
3. https://doi.org/10.1039/C7CC06010F

Tags

Chemical manufacturing

Continuous multi-step synthesis

Multi-component reaction (MCR)

Twin screw extrusion (TSE)

Solvent

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/17693
Date	13 February 2020
Creators	Crawford, Deborah E., Miskimmin, C.K., Cahir, J., James, S.L.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, Accepted manuscript
Rights	© The Royal Society of Chemistry 2017. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.