Surface energetics play a key role in the delivery of a dry powder inhaler
formulation into the lungs, as there must be a sufficient balance of adhesive and
cohesive forces to allow optimal lung delivery. In this study, measuring the
surface energies of a set of single drug and carrier (budesonide or theophylline
with either mannitol or lactose) with different levels of surfactant using Inverse
Gas Chromatography, and comparing them to their lung deposition performance
using a Next Generation Impactor established a relationship between the two. A
1:10 mixing ratio of budesonide with either carrier was found to have the highest
FPF. Coating the carriers with 0.05% sodium lauryl sulphate resulted in a further
increase in the FPF when using either budesonide or theophylline as the API,
and the same results were seen when a sonocrystallised version of the API was
substituted for the micronised form. The calculated IGC values then showed that
the highest performing formulations had the lowest dispersive energy and total
free surface energy. Furthermore, a trend was observed in the work of adhesion
(Wa) and work of cohesion (Wc) for each set of formulations depending on which
API was chosen, where for the less polar drug (budesonide) a higher Wa/Wc
ratio was associated with the highest formulation performance, and for the more polar drug (theophylline) a smaller Wa/Wc ratio was associated with the highest formulation performance, enabling the estimation of lung performance for a set of
single drug and carrier using their surface energy data. / Kuwait’s government and the Ministry of Health of Kuwait
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/19846 |
| Date | January 2022 |
| Creators | Jamal, Abdullateef J.A.M.A. |
| Contributors | Assi, Khaled H., Vangala, Venu R. |
| Publisher | University of Bradford, School of Pharmacy. Faculty of Life Sciences |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Thesis, doctoral, PhD |
| Rights | <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>. |
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