Design, Synthesis and Biological Evaluation ofnovel lipoamino acid-based glycolipids for oral drug delivery.

Description

No / A series of lipoamino acid-based glycolipids were synthesised. Suitably derivatised lipoamino acid derivatives were prepared and conjugated to monosaccharides (including glycosyl azides, isothiocyanates, thiols and sulphones) to yield novel O-, N-, S- and C-linked glycolipids in good yields. Their potential to improve the oral absorption of piperacillin is reported.

Links & Downloads

1. Falconer, R.A. and Toth, I. (2007). Design, Synthesis and Biological Evaluation ofnovel lipoamino acid-based glycolipids for oral drug delivery. Bioorganic & Medicinal Chemistry. Vol. 15, No. 22, pp. 7012-7020.
2. http://hdl.handle.net/10454/3751
3. https://doi.org/10.1016/j.bmc.2007.07.048

Tags

Drug delivery;

Glycolipid

Lipoamino acid

Liposaccharide

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/3751
Date	January 2007
Creators	Falconer, Robert A., Toth, I.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, No full-text available in the repository