The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites.

Description

no / Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites. Here we show that cryptolepine interacts with the CC sites of the DNA fragment d(CCTAGG)2 in a base-stacking intercalation mode.

Links & Downloads

1. Lisgarten, J. N., Coll, M., Portugal, J., Wright, C. W. and Aymami, J. (2001). The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. Nature Structural Biology, Vol. 9, pp. 57 - 60.
2. http://hdl.handle.net/10454/4045
3. https://doi.org/10.1038/nsb729

Tags

Cryptolepine

Indoloquinoline alkaloid

Antimalarial drugs

DNA intercalation

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4045
Date	January 2001
Creators	Lisgarten, J.N., Coll, M., Portugal, J., Wright, Colin W., Aymami, J.
Publisher	Nature
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, published version paper