To evaluate repeatability and reproducibility of macular thickness measurements in visually normal eyes
using the Topcon 3D OCT-1000.
Methods: Phase 1 investigated scan repeatability, the effect of age and pupil dilation. Two groups (6 younger and 6 older
participants) had one eye scanned 5 times pre and post- dilation by 1 operator. Phase 2 investigated between-operator,
within and between-visit reproducibility. 10 participants had 1 un-dilated eye scanned 3 times on 2 separate visits by 2
operators.
Results: Phase 1: No significant difference existed between repeat scans (p=0.75) and no significant difference was found
pre- and post-dilation (p=0.54). In the younger group variation was low (95% limits ± 3.62 m) and comparable across all
retinal regions. The older group demonstrated greater variation (95% limits ± 7.6 m).
Phase 2: For a given retinal location, 95% confidence limits for within-operator, within-visit reproducibility was 5.16 m.
This value increased to 5.56 m for the same operator over two visits and to 6.18 m for two operators over two visits.
Conclusion: A high level repeatability, close to 6 m, of macular thickness measurement is possible using the 3D OCT-
1000. Measured differences in macular thickness between successive visits that exceed 6 m in pre-presbyopic individuals
are therefore likely to reflect actual structural change. OCT measures are more variable in older individuals and it is
advisable to take a series of scans so that outliers can be more easily identified.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/6384 |
| Date | January 2009 |
| Creators | Bruce, Alison, Pacey, Ian E., Dharni, Poonam, Scally, Andy J., Barrett, Brendan T. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
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