y / The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded
Lister rats received sub-chronic phencyclidine (PCP) (2mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days’ washout. PCP-treated rats then
received PNU-120596 (10mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive
deficit in the extra-dimensional shift (EDS) phase of the task (p < 0.001, compared with vehicle). PNU-120596 significantly improved performance of
PCP-treated rats in the EDS phase of the attentional set-shifting task (p < 0.001). In conclusion, these data demonstrate that PNU-120596 improves
cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. / This work was partially funded by Johnson & Johnson Pharmaceutical Research and Development.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/8463 |
| Date | 18 December 2011 |
| Creators | McLean, Samantha L., Idris, Nagi F., Grayson, Ben, Gendle, D.F., Mackie, C., Lesage, A.S., Pemberton, D.J., Neill, Joanna C. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted Manuscript |
| Rights | The final, definitive version of this paper has been published in Journal of Psychopharmacology, 26(9) by SAGE Publications Ltd, All rights reserved. © 2012 SAGE Publications Ltd. |
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