Yes / Context: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer.
Objective: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer.
Materials and methods: Urinary biomarkers concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis.
Results: A 5-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set.
Discussion and conclusion: This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer. / This work has been supported in part by the European Commission Program DIPROMON - HEALTH-F5-2012-306157-2: Development of an integrated protein- and cell-based device for non-invasive diagnostics in the urogenital tract.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/9897 |
| Date | 31 July 2015 |
| Creators | De Paoli, M., Perco, P., Mühlberger, I., Lukas, A., Pandha, H.S., Morgan, Richard, Feng, G.J., Marquette, C. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted Manuscript |
| Rights | © 2015 Taylor & Francis. This is an Author's Original Manuscript of an article published by Taylor & Francis in Biomarkers on 31 Jul 2015, available online at http://www.tandfonline.com/10.3109/1354750X.2015.1068867 |
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