Lupus anticoagulants (LA) are immunoglobulins (IgG, IgM, IgA or a mixture) that interfere with in vitro phospholipids (PL) dependent coagulation tests. Variable test results among LA positive individuals are due to the heterogeneous nature of the antibodies and differences in reagent/instrument systems. A laboratory’s ability to differentiate LA from other coagulation abnormalities and to accurately establish PL dependence is determined by the sensitivity and responsiveness of screening assays and specificity of confirmatory tests. The Third International Survey on Lupus Anticoagulants (ISLA-3) was organized to assess current protocols for LA testing and determine the sensitivity and specificity of confirmatory tests. A written survey and samples for evaluation were sent to 41 participants from five continents. A majority of laboratories performed 2 screening tests and all performed mixing studies if a screening test was abnormal. Confirmatory tests were done if mixing studies suggested the presence of an inhibitor. New confirmatory assays proved to be more specific than methods previously in place.Ball State UniversityMuncie, IN 47306 / Center for Medical Education
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/185214 |
| Date | January 1995 |
| Creators | Barna, Linda Kathern |
| Contributors | Muncie Center for Medical Education (Indiana University School of Medicine), Triplett, Douglas A. |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | 1 v. (various foliations) : ill. ; 28 cm. |
| Source | Virtual Press |
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