The increase in the rate of diabetes has coincided with drastic increases in high fructose corn syrup (HFCS) consumption. There is much controversy over whether these increases are linked. Fructose consumption has been under much scrutiny, as fructose metabolism is not regulated by phosphofructokinase, the major regulator of the glycolytic pathway. Studies have shown that high levels of fructose consumption lead to decreased insulin sensitivity through a mechanism that involves the disruption of insulin signaling by abnormal lipid accumulation. Recent studies have indicated that HFCS consumption similarly affects the body; however, results have been inconsistent. This paper proposes a study that focuses on revealing whether HFCS consumption increases the predisposition to developing type II diabetes by lowering insulin sensitivity, while taking in contributing factors such as amount of consumption, study duration, and subject characteristics. In this proposed study, subjects will moderately consume HFCS at 15% of daily energy requirements (DER) for six months. It is expected that the moderate HFCS consumption will induce insulin resistance through inducing hepatic lipid accumulation.
| Identifer | oai:union.ndltd.org:CLAREMONT/oai:scholarship.claremont.edu:cmc_theses-1476 |
| Date | 01 January 2012 |
| Creators | Nishioka, Julia A. |
| Publisher | Scholarship @ Claremont |
| Source Sets | Claremont Colleges |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | CMC Senior Theses |
| Rights | © 2012 Julia A. Nishioka, default |
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