In this paper, we provide a mathematical model of the effect of aspirin on blood clotting. The model tracks the enzyme prostaglandin H synthase and an important blood clotting factor, thromboxane A2, in the form of thromboxane B2. Through model analysis, we determine conditions under which the reactions of prostaglandin H synthase are self-sustaining. Lastly, through numerical simulations, we demonstrate that the model accurately captures the steady-state chemical concentrations of interest in blood, both with and without aspirin treatment.
| Identifer | oai:union.ndltd.org:CLAREMONT/oai:scholarship.claremont.edu:scripps_theses-1631 |
| Date | 01 January 2015 |
| Creators | Johng, Breeana J |
| Publisher | Scholarship @ Claremont |
| Source Sets | Claremont Colleges |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Scripps Senior Theses |
| Rights | © 2015 Breeana J. Johng, default |
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