El objetivo de esta investigación fue evaluar la actividad antibacteriana de la Combinación de Drogas 3Mix, formada por Metronidazol, Ciprofloxacina y Minociclina, contra microorganismos anaerobios estrictos y facultativos prevalentes en conductos radiculares de piezas deciduas con necrosis pulpar. Se utilizaron seis cepas ATCC® de bacterias anaerobias estrictas y facultativas para probar la susceptibilidad a la combinación de Drogas 3Mix y sus componentes mediante el Método de Disco Difusión Kirby – Bauer en medio anaerobio. Se realizó la lectura de los resultados a las 24 y 48 horas observándose amplios halos de inhibición en todas las bacterias. La mayor actividad antibacteriana fue producida por la solución de Metronidazol seguida por la combinación de Drogas 3Mix, Minociclina y Ciprofloxacina el cual mostró el menor efecto antibacteriano. La bacteria Prevotella melaninogénica fue la mas susceptible a la combinación de Drogas 3Mix demostrando mayor efectividad sobre microorganismos anaerobios estrictos y la ausencia de antagonismo farmacológico entre sus componentes. / -- The aim of this study was to evaluate the antibacterial activity of the Mixture of Drugs 3Mix, formed by Metronidazole, Ciprofloxacin and Minocycline against the main strict and facultative anaerobic microorganisms in deciduous teeth with necrotic pulps. Six ATCC® stocks of facultative and strict anaerobic bacterias (Porphyromona, Prevotellas, Peptostreptococcus, Lactobacillus, Actinomyces, and Streptococcus) were used to prove the susceptibility to the Mixture of Drugs 3Mix and its components by means Disk Difussion Kirby – Bauer’s method in anaerobic conditions. The reading of results was made at 24 and 48 hours respectively, being observated wide inhibition halos in all the bacteria tested. The biggest antibacterial activity was produced by the Metronidazol solution followed by the mixture of Drugs 3Mix, Minocycline and Ciprofloxacin which showed the lowest antibacterial effect. Prevotella melaninogénica was the most susceptible to the Mixture of Drugs 3Mix demonstrating high effectiveness on strict anaerobic microorganisms and the absence of pharmacologic antagonism between its components. / Tesis
| Identifer | oai:union.ndltd.org:Cybertesis/oai:cybertesis.unmsm.edu.pe:cybertesis/2151 |
| Date | January 2007 |
| Creators | Quispe Salcedo, Angela |
| Contributors | Castañeda Mosto, María Magdalena |
| Publisher | Universidad Nacional Mayor de San Marcos |
| Source Sets | Universidad Nacional Mayor de San Marcos - SISBIB PERU |
| Language | Spanish |
| Detected Language | Spanish |
| Type | info:eu-repo/semantics/bachelorThesis |
| Format | application/pdf |
| Source | Universidad Nacional Mayor de San Marcos, Repositorio de Tesis - UNMSM |
| Rights | info:eu-repo/semantics/openAccess |
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