Evolution of microRNAs located within Hox gene clusters

Description

MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in post‐transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss.

Links & Downloads

1. urn:nbn:de:bsz:15-qucosa2-319125
2. https://ul.qucosa.de/id/qucosa%3A31912
3. https://ul.qucosa.de/api/qucosa%3A31912/attachment/ATT-0/

Tags

Biochemistry, Evolutionary biology, RNA

info:eu-repo/classification/ddc/572.8

ddc:572.8

Additional Fields

Identifer	oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:31912
Date	16 October 2018
Creators	Tanzer, Andrea, Amemiya, Chris T., Kim, Chang-Bae, Stadler, Peter F.
Source Sets	Hochschulschriftenserver (HSSS) der SLUB Dresden
Language	English
Detected Language	English
Type	info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text
Rights	info:eu-repo/semantics/openAccess
Relation	1552-5015