MicroRNAs (miRNAs) form an abundant class of nonâcoding RNA genes that have an important function in postâtranscriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss.
Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:31912 |
Date | 16 October 2018 |
Creators | Tanzer, Andrea, Amemiya, Chris T., Kim, Chang-Bae, Stadler, Peter F. |
Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
Language | English |
Detected Language | English |
Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
Rights | info:eu-repo/semantics/openAccess |
Relation | 1552-5015 |
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