Swine stocks are endemically infected with the major porcine pathogen Streptococcus (S.)
suis. The factors governing the transition from colonizing S. suis residing in the tonsils and the
exacerbation of disease have not yet been elucidated. We analyzed the sudden death of fattening
pigs kept under extensive husbandry conditions in a zoo. The animals died suddenly of septic shock
and showed disseminated intravascular coagulopathy. Genotypic and phenotypic characterizations
of the isolated S. suis strains, a tonsillar isolate and an invasive cps type 2 strain, were conducted.
Isolated S. suis from dead pigs belonged to cps type 2 strain ST28, whereas one tonsillar S. suis
isolate harvested from a healthy animal belonged to ST1173. Neither S. suis growth, induction of
neutrophil extracellular traps, nor survival in blood could explain the sudden deaths. Reconstituted
blood assays with serum samples from pigs of different age groups from the zoo stock suggested
varying protection of individuals against pathogenic cps type 2 strains especially in younger pigs.
These findings highlight the benefit of further characterization of the causative strains in each case by
sequence typing before autologous vaccine candidate selection.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84651 |
| Date | 11 April 2023 |
| Creators | Hennig-Pauka, Isabel, Imker, Rabea, Mayer, Leonie, Brügmann, Michael, Werckenthin, Christiane, Weber, Heike, Menrath, Andrea, de Buhr, Nicole |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2076-0817, 249 |
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