Nocardia spp. are filamentous Actinobacteria of the order
Corynebacteriales and mostly known for their ability to
cause localized and systemic infections in humans. However,
the onset and progression of nocardiosis is only poorly understood,
in particular the mechanisms of strain-specific presentations.
Recent genome sequencing has revealed an extraordinary
capacity for the production of specialized small
molecules. Such secondary metabolites are often crucial for
the producing microbe to survive the challenges of different
environmental conditions. An interesting question thus concerns
the role of these natural products in Nocardia-associated
pathogenicity and immune evasion in a human host. In
this review, a summary and discussion of Nocardia metabolites
is presented, which may play a part in nocardiosis because
of their cytotoxic, immunosuppressive and metal-chelating
properties or otherwise vitally important functions.
This review also contains so far unpublished data concerning
the biosynthesis of these molecules that were obtained by
detailed bioinformatic analyses.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:94479 |
| Date | 19 November 2024 |
| Creators | Engelbrecht, Alicia, Saad, Hamada, Gross, Harald, Kaysser, Leonard |
| Publisher | Karger |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2673-1665, 2673-1673, 10.1159/000516864 |
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