The interaction of 4-(1'-[8'-(1''-pyrenyl)naphthyl])-2,6-diaminopyridine bis-glycamide bishydrocholride known to have anticancer properties with deoxyribonucleic acid (DNA) had been studied on a modified gold electrode by self-assembled monolayer using cyclic voltammetry. K4Fe (CN)6 was used as a probe to obtain electrochemical information on the electrode surface.
A bare gold (Au) electrode was modified with cysteamine and our results showed no change in the limiting steady state current as compared to the bare Au electrode. There was a reduction in the steady state current after the modification of the gold electrode with DNA. Immobilization of the DNA modified gold electrode with the anticancer compound also revealed a further reduction in the steady state current. The reduction in the steady state current is attributed to the receptor and DNA forming a nonelectrochemical complex due to the intercalation of the receptor and DNA on the gold electrode surface.
| Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etd-2570 |
| Date | 17 December 2011 |
| Creators | Kamasah, Alexander |
| Publisher | Digital Commons @ East Tennessee State University |
| Source Sets | East Tennessee State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Electronic Theses and Dissertations |
| Rights | Copyright by the authors. |
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