Ampicillin-sulbactam was compared with cefamandole in the treatment of bacterial pneumonia in elderly patients. Clinical improvement ard hospital discharge occurred in 25 of 26 patients in the ampicillin-sulbactam group vs. 20 of 23 in the cefamardole group (P >.06). Etiologic agents isolated from adequate sputum samples were more likely to be eradicated with ampicillin-sulbactam (24/26) than with cefamandole (15/23) (P <.05). The most common organisms isolated from elderly patients with pneumonia included Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae. M. catarrhalis was eradicated from sputum in 2 of 5 patients treated with cefamandole, and these isolates had relatively high minimal inhibitory concentrations (8 to 16 μg/mL).
Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-14663 |
Date | 01 December 1993 |
Creators | Berk, S. L., Musgrave, T., Kalbfleisch, J., Hatcher, E. |
Publisher | Digital Commons @ East Tennessee State University |
Source Sets | East Tennessee State University |
Detected Language | English |
Type | text |
Source | ETSU Faculty Works |
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