Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2016-09-19T11:49:34Z
No. of bitstreams: 1
2011 - Michel Jos? Sales A. Helayel.pdf: 11350186 bytes, checksum: ab1a4bf6f150ee6e971e58207f995bff (MD5) / Made available in DSpace on 2016-09-19T11:49:34Z (GMT). No. of bitstreams: 1
2011 - Michel Jos? Sales A. Helayel.pdf: 11350186 bytes, checksum: ab1a4bf6f150ee6e971e58207f995bff (MD5)
Previous issue date: 2011-03-16 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This study aimed to evaluate the protective effect of acetamid in experimental poisoning by
Pseudocalymma elegans in sheep, goats and rabbits, in order to prove indirectly that
monofluoroacetate (MF) is responsible for the clinical signs and death of animals that ingested
the plant. Experiments were performed to determine for sheep and goats the lethal dose of P.
elegans collected in Rio Bonito, RJ, in different seasons, and to adjust the dose of acetamid to be
administered. In the first experiment, four animals received 1.0g/kg of fresh P. elegans, and two
others were pretreated with 2.0g/kg of acetamid. None of the animals showed clinical signs or
died. Possibly, the plant could be less toxic, since it was collected at the end of the rainy season.
In the second experiment, two sheep and two goats received 0.67 and 1.0g/kg of the dried plant,
after pretreatment with 2.0 and 3.0g/kg of acetamid, respectively. All animals died, as the
administered doses of P. elegans were very high. In the third experiment, two sheep and two
goats received 0.333g/kg of dried P. elegans after previous administration of 2.0g/kg of
acetamid; a week later, the protocol above was repeated, but without the antidote. In experiments
with rabbits, doses of 0.5 and 1.0g/kg of dried P. elegans were given after administration of
3.0g/kg of acetamid; seven days later, the same protocol was repeated, except the administration
of acetamide. This procedure, when acetamid was administered before, prevented the appearance
of clinical signs and death of sheep, goats and rabbits. But the animals not treated with acetamid
showed symptoms of poisoning and died. Clinically, the sheep and goats had tachycardia,
engorged jugular vein, positive venous pulse, lateral recumbence, and muscle tremors. In the
"dramatic phase?, the animals fell into lateral position, stretched the limbs, were paddling and
died within minutes. The rabbits showed apathy, muscle tremors, vocalization and lateral
decumbence minutes before death. At postmortem examination, the sheep and goats had
engorged jugular veins and atria, dilated Vena cava cranialis and caudalis, as well as pulmonary
edema, hepatic congestion and edema of the gallbladder subserosa. In rabbits, the main
macroscopic alterations were dilated atria, engorged Vena cava cranialis and caudalis, and
congested liver and diaphragm vessels. Histopathology revealed, in two sheep and one goat,
vacuolar-hydropic degeneration of the distal convoluted kidney tubules, together with
caryopicnosis. In the rabbits, the liver showed severe congestion with numerous shock
corpuscles. The experimental results show indirectly that MF is to be held responsible for death
of the animals that ingested P. elegans; since "acetate donor" compounds, such as acetamid, are
capable to reduce the competitive inhibition of MF for the same active site (Coenzyme A) which
prevents the formation of fluorocitrate, its active metabolite, formed in the body through the socalled
"lethal synthesis". / O presente trabalho teve como objetivo avaliar o efeito protetor da acetamida nas
intoxica??es experimentais por Pseudocalymma elegans (Bignoniaceae) em ovinos, caprinos e
coelhos, com a finalidade de comprovar indiretamente que o monofluoroacetato ? respons?vel
pela sintomatologia e morte dos animais que ingerem essa planta. Foram realizados experimentos
para determinar a dose letal da planta coletada em Rio Bonito, RJ, em diferentes ?pocas do ano
para ovinos e caprinos e ajustar a dose de acetamida a ser administrada. No primeiro
experimento, dois ovinos e dois caprinos receberam 1,0 g/kg de P. elegans fresca e um animal de
cada esp?cie foi tratado previamente com 2,0 g/kg de acetamida. Nenhum animal apresentou
altera??es cl?nicas ou morreu. Ao que tudo indica a planta poderia estar menos t?xica, j? que foi
coletada no fim da esta??o das ?guas. No segundo experimento, dois ovinos e dois caprinos
receberam 0,67 e 1,0 g/kg da planta dessecada, ap?s tratamento pr?vio, com 2,0 e 3,0 g/kg de
acetamida, respectivamente. Todos os animais morreram, pois administramos doses muito altas
de P. elegans. No terceiro experimento, dois ovinos e dois caprinos receberam, 0,333 g/kg de P.
elegans dessecada, ap?s administra??o pr?via de 2,0 g/kg de acetamida. Uma semana depois, o
protocolo acima foi repetido, por?m sem o ant?doto. Nos experimentos com coelhos, foram
administradas doses de 0,5 e 1,0 g/kg de P. elegans dessecada ap?s a administra??o de 3,0 g/kg
de acetamida. Sete dias depois, o mesmo protocolo foi repetido, com exce??o da administra??o
de acetamida. Esta, quando administrada previamente, evitou o aparecimento dos sinais cl?nicos e
a morte dos ovinos, caprinos e coelhos, j? os animais n?o tratados com acetamida apresentaram
sintomatologia e morreram. Clinicamente, os ovinos e caprinos manifestaram taquicardia,
jugulares ingurgitadas, pulso venoso positivo, dec?bito esternal e tremores musculares. Na ?fase
dram?tica?, os animais ca?am em dec?bito lateral, esticavam os membros, faziam movimentos de
pedalagem e morriam em poucos minutos. Nos coelhos observaram-se apatia, tremores
musculares, dec?bito lateral e vocaliza??o minutos antes da morte. A avalia??o macrosc?pica
revelou, nos ovinos e caprinos, jugulares ingurgitadas, aur?culas, veia cava caudal e cranial
dilatadas, al?m de edema pulmonar, congest?o hep?tica e edema na subserosa da ves?cula biliar.
Nos coelhos as principais altera??es observadas foram aur?culas dilatadas, veia cava caudal e
cranial ingurgitadas, f?gado e vasos do diafragma congestos. O exame histopatol?gico revelou,
em dois ovinos e um caprino, degenera??o hidr?pico-vacuolar dos t?bulos urin?feros contornados
distais associada ? cariopicnose. Nos coelhos havia congest?o hep?tica acentuada com numerosos
corp?sculos de choque. Nossos resultados comprovam, de forma indireta, que o MF ?
respons?vel pela morte dos animais que ingerem essa planta, uma vez que compostos ?doadores
de acetato? como a acetamida, s?o capazes de reduzir a inibi??o competitiva do MF pelo mesmo
s?tio ativo (Coenzima A), o que impede a forma??o do fluorocitrato, seu metab?lito ativo,
formado no organismo por meio da denominada ?s?ntese letal?.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1206 |
| Date | 16 March 2011 |
| Creators | Helayel, Michel Jos? Sales Abdalla |
| Contributors | Tokarnia, Carlos Hubinger, Peixoto, Paulo Vargas, Nogueira, Vivian de Assun??o Nogueira, Gra?a, Fl?vio Augusto Soares, Fran?a, Ticiana do Nascimento, Dobereiner, Jurgen, Brito, Marilene de Farias |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 7 REFER?NCIAS BIBLIOGR?FICAS ADESP. 2007. Associa??o de Empresas Controladoras de Pragas do Estado. Dispon?vel em http://www.adesp.org.br acesso em 07/07/07. ALLENDER, W. J. Determination of sodium fluoroacetate (1.080) in biological tissues. Journal of Analytical Toxicology, Niles, v. 14, n. 1, p. 45-49, Jan./Feb. 1990. ANCLIVEPA. Mist?rio no zool?gico de S?o Paulo: Boletim informativo n. 33. 2004. Dispon?vel em: <http://www.anclivepa-sp.org.br/rev-33-01.htm>. Acesso em: 06 jul. 2007. ANNISON, E. F; HILL, K.J; LINDSAY, D.B; PETERS, R.A. Fluoroacetate poisoning in sheep. Journal Comparative Pathology, Liverpool, v. 70, p. 145-155, 1960. APEVISA, 2009. Apevisa apreende 302 frascos com raticida ilegal. Dispon?vel em: <http://www.saude.pe.gov.br/noticias.php?codigo=1066&pagina=2&publicar=1>. Acesso em: 20 fev. 2009. APTEKMAN, K. P.; ALTWEGG, D.; KITAMURA, E. A.; VICENTE, P. C.; SAKATE, M. . Estudo retrospectivo de felinos intoxicados por monofluoroacetato de s?dio. In: 7? Mostra Cient?fica da FMVZ-UNESP, Botucatu, 2003, Botucatu. Anais da 7a Mostra Cient?fica da FMVZ-UNESP, Botucatu. Botucatu : FMVZ-UNESP, v. 7. p. 58-58, 2003. ATZERT, S.P. A review of sodium monofluoroacetate its properties, toxicology and use in predator and rodent control. Special Scientific Repart on Wildlife 146. U.S. Departament of the interior, 1971. AULERICH, R. J.; RINGER, R. K.; SAFRONOFF, J. Primary and secondary toxicity of warfarin, sodium monofluoroacetate, and methyl parathion in mink. Archives of Environmental Contamination and Toxicology, v.16, p.357-366, 1987. BALCOMB, R., C. A. BOWEN II, H. O. WILLIAMSON. Acute and sublethal effects of 1080 on starlings. Bulletin of Environmental Contamination and Toxicology, v.31, p.692- 698, 1983. BALLANI, T. S. L; BAULI, J.D; BURIOLA, A.A; FARIA, S.T; OLIVEIRA, M.L.F. Intoxica??o por produtos clandestinos em maring?-paran?. In: CONGRESSO DE TOXICOLOGIA CL?NICO-LABORATORIAL. 1., 2008, Porto Alegre. Anais... Porto Alegre: [s.n.], 2008. N?o paginado. BARBASH, J.E.; RESEK, E.A. Pesticides in ground water: Distribution, trends, and governing factors. Ann Arbor Press, Chelsea, MI. 588p, 1996. BARBOSA, J. D; OLIVEIRA, C.M.C;. TOKARNIA, C.H; RIET-CORREA, F. Compara??o da sensibilidade de bovinos e b?falos ? intoxica??o por Palicourea marcgravii (Rubiaceae). Pesquisa Veterin?ria Brasileira, Serop?dica, v.23, n.4, p. 167-172, out./dez. 2003. 32 BARNES, R. A.; GILBERT, M. E. A. Investiga??o qu?mica preliminar de v?rias plantas brasileiras: presen?a de alcal?ides, saponinas e outras subst?ncias. Boletim do Instituto de Qu?mica Agr?cola, Rio de Janeiro, v. 58, p. 9-26, 1960. BEASLEY, M. Guidelines for the safe use of sodium fluoroacetate (1080). New Zealand: Occupational Safety & Health Service. 2002. 20 p. BELLUOMINI, H.E., ARAUJO, P., ROSENFELD, G., PENHA, A.M. Beitrag zur Serumtherapie bei experimenteller Vergiftung vonrindern mit dem Gift der Klapperschlange. Deutsche Tier?rztliche Wochenschrift, Hannover, v. 90, p. 93-95, 1983. BENNETS, H. W.; BECK, A. B.; HARLEY, R. The pathogenesis of "falling disease". Australian Veterinary Journal, Brunswick, v. 24, p. 237-24, 1948. BLANCO, J.M.; GEE, G.; WILDT, D.E.; DONOGHUE, A.M. Species variation in osmotic, cryoprotectant, and cooling rate tolerance in poultry, eagle, and peregrine falcon spermatozoa. Biology of Reprodution. v.63, n.4, p.1164-71, 2000. BOSAKOWSKI, T.; LEVIN, A.A. Serum citrate as a peripheral indicator of fluoroacetate and fluorocitrate toxicity in rats and dogs. Toxicology and Applied Pharmacology, v.85, p.428- 436, 1986. BOWMAN, R. H. Inhibition of citrate metabolism by sodium fluoroacetate in the perfused rat heart and the effect on phosphofructokinase activity and glucose utilization. Biochemical Journal, v. 93, n. 2, p. 13-15, 1964. BRANCO, P.M.; CHAVES, M.L.S.C. A Mineralogia e alguns de seus minerais raros ou de g?nese ex?tica. Terra e Did?tica,v.2, n.1, p.75-85, 2006. BRASIL. Portaria n? 321, de 28 de julho de 1997. Normas Gerais para Registro de Desinfetantes Domissanit?rios. Dispon?vel em: <http://www.pragas.com.br/legislacao/bancodedados/port321-97.php>. Acesso em: 09 ago. 2007. BRISCOE, H. V. A. Report to Director of Research, Ministry of Supply, 1942. BROCKMANN, J. L.; McDOWELL, A. V.; LEEDS, W. G. Fatal poisoning with sodium fluoroacetate and fluorocitrate toxicity in rats and dogs. Journal of the American Medical Association, v. 159, p. 1529-1532, 1955. BURGER, I. H.; FLECKNELL, P. A. Poisoning. In: CHANDLER, E. A.; GASKELL, C. J.; GASKELL, R. M. Feline Medicine and Therapeutics. 2. ed. New York: Blackwell, 1994, p. 656-677. BURKE, D. G.; LEW, D. K. T.; COMINOS, X. Determination of fluoroacetate in biological matrixes as the dodecyl ester. The Journal of the Association of Official Analytical Chemists, v. 72, p. 503-507, 1989. 33 CALVER, M. C.; KING, D. R. Controlling vertebrate pests with fluoroacetate: lessons in wildlife management, bio-ethics, and co-evolution. Journal of Biological Education, n. 20, v. 4, p. 257-262, 1986. CAMARGO, W. A. Uma nova ?erva-de-rato? t?xica para bovinos Palicourea barbiflora; compara??o com a Palicourea marcgravii var. pubescens e com Psychotria officinalis, Rubiaceae. Arquivos do Instituto Biol?gico, S?o Paulo, v. 29, p. 1-11, 1962. CASCON, C. S; MORS, W. B. Subst?ncias isoladas da Palicourea marcgravii St.Hil: uma nova s?ntese da N-metil-tiramina. Anais da Associa??o Brasileira de Qu?mica, v. 21, p. 53- 60, 1962. CASPER, H.H.; McMAHON, T.L.; PAULSON, G.D. Capillary gas chromatographic-mass spectrometric determination of fluoroacetate residues in animal tissues. Journal of Association Off. Analytical Chemistry, v.68, n. 4, p. 722-725, 1985. CHEHNOWETH, M. B. Monofluoroacetic acid and related compounds. Journal Pharmacology Experimental Therapeutics, Baltimore, v. 97, n. 2, p. 383-406, 1949. CHENOWETH, M. B. Monofluoroacetic acid and related compounds. Journal of Pharmacology and Experimental Therapeutics, v. 97, n. 4, p. 383-424, 1949. CHENOWETH, M.B.; GILMAN, A. Studies on the pharmacology of fluoroacetate. l - Species response to fluoroacetate. Journal of Pharmacology and Experimental Therapeutic, v.87, p. 90-103, 1946. CHENOWETH, M.B.; KANDEL, A.; JOHNSON, L.B.; BENNETT, D.R. Factors influencing fluoroacetate poisoning. Journal of Pharmacology and Experimental Therapeutic, v. 102, p.31-49, 1951. CHI, C-H.; CHEN, K-W.; CHAN, S-H.; WU, M-H.; HUANG, J-J. Clinical presentation and prognostic factors in sodium monofluoroacetate intoxication. Clinical Toxicology, v.34 , p.707-712, 1996. CHI, C-H.; LIN, T-K.; CHEN, K-W. Hemodynamic abnormalities in sodium monofluoroacetate intoxication. Human and Experimental Toxicology, v.18, p.351-353, 1999. CHUNG, H.M. Acute renal failure caused by acute monofluoroacetate poisoning. Veterinary and Human Toxicology, v.26, p. 29-32, 1984. CHURCHILL, R. 1080 Sodium fluoroacetate toxicity in dogs: control and therapy series. 1996. 846 p. Thesis (Doctorate in Veterinary Science) - University of Sydney, 1996. CHURCHILL, R.; CORKHILL, C.; RICHARD, M. 1.080 poisoning in dogs. 2007. Dispon?vel em: <http://www.theveterinarian.com.au./features/article685.asp>. Acesso em: 05 Jul. 2007. CLARKE, D. D. Fluoroacetate and fluorocitrate: mechanism of action. Neurochemical Research, New York, v. 16, n. 9, p. 1055-1058, Sep. 1991. 34 CLARKE, D. D.; NICKLAS, W. J.; BERL, S. Tricarboxylic acid-cycle metabolism in brain: effect of fluoroacetate and fluorocitrate on the labelling of glutamate aspartate, glutamine and -amino butyrate. Biochemistry Journal, London, v. 120, n. 2, p. 345-351, Nov. 1970. CLARK, R.; WEISS, K. E. Factors contributing towards bloat in ruminants. Journal of South African Veterinarian Medical Association, [S. l.], v. 23, n. 2, p. 103-106, 1952. COLLICCHIO-ZUANAZE, R. C. et al. Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electroardiographic evaluation. Human Experimental Toxicology, London, v. 25, n. 4, p. 175-182, 2006. CONSORTE, L. B., PEIXOTO, P. V.; TOKARNIA, C. H. Intoxica??o experimental por Pseudocalymma elegans (bignoniaceae) em ovinos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 14, n. 4, p. 123-133, out./dez. 1994. COOK, C. J; EASON, C.T; WICKSTROM, M; DEVINE, C.D. Developments of antidotes for sodium monofluoroacetate (1080). Biomarkers, v. 6, p 72-76, 2001. CORTES, P. R. Una etiologia de la borrachera del llano. Revista Ganagrinco, Caracas, v. 4, n. 18, 1969/71. Pagina??o irregular. COSTA, M.V., NASCIMENTO, E.F., PESSOA, J.M.; COSTA; W.R. Les?es em bovinos intoxicados por Palicourea marcgravii St, Hil. Arquivos Brasileiros Medicina Veterin?ria e Zootecnia, Belo Horizonte, v. 36, n. 5, p. 571-580, 1984. COUCEIRO, J. E. M.; SILVA, A. C. C.; SILVA, J. A. Observa??es e ensaios sobre a alegada intoxica??o de bovinos por plantas, no Estado de Pernambuco. In: CONGRESSO BRASILEIRO DE MEDICINA VETERIN?RIA, 15., 1976. Rio de Janeiro. Resumos... Rio de Janeiro: [s. n.], 1976. COWAN, P. E. The ecological effects of possum on the New Zealand environment. In: SYMPOSIUM ON TUBERCULOSIS, 1991. Palmerston North. Proceedings? Massey University: Veterinary Continuing Education, p. 132, 1991. CUNHA, L. C. Avalia??o dos efeitos t?xicos de Mascagnia rigida em ratos. Estudo anatomopatol?gico. Compara??o entre metodologias cromatogr?ficas para detec??o do fluoroacetato de s?dio. 2008. 100 p. Disserta??o (Mestrado em Patologia Experimental e Comparada) - Universidade de S?o Paulo, 2008. CUNHA, L.C.; GORNIAK, S.L.; HARAGUCHI, M.; RIET-CORREA, F.; XAVIER, F.G.; FLORIO, J.C. 2006. Palicourea marcgravii e Mascagnia rigida: um estudo por cromatografia em camada delgada (CCD). II Simp?sio de P?s-Gradua??o e XV Semana Cient?fica Prof. Dr. Benjamin Eurico Malucelli, S?o Paulo, em CD-ROM. (Resumo). DEMARCHI, A.C.C.; MENEZES, M.L.; MERCADANTE, A.; VASSILLIEF, I. Determination of the sodium monofluoroacetate in serum by gas chromatography. Chromatographia, v. 54, p.402-404, 2001. 35 D?BEREINER, J; GAVA, A; CONSORTE, L.B; TOKARNIA, C.H. Intoxica??o experimental por Mascagnia pubiflora (Malpighiaceae) em coelhos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 6, n. 2, p. 51-57, jan./mar. 1986. D?BEREINER, J.; PEIXOTO, P. V.; TOKARNIA, C. H. Intoxica??o experimental por Arrabidaea bilabiata (Bignoniaceae) em coelhos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 4, n. 3, p. 89-96, jan./mar. 1984. D?BEREINER, J.; REZENDE, A. M. L.; TOKARNIA, C. H. Intoxica??o experimental por Baccharis coridifolia em coelhos. Pesquisa Agropecu?ria Brasileira, Rio de Janeiro, v. 11, p. 27 ? 35, 1976. D?BEREINER, J.; TOKARNIA, C. H. Intoxica??o de bovinos pela ?erva-de-rato? (Palicourea marcgravii St. Hil.) no vale do Itapicuru, Maranh?o. Arquivos do Instituto de Biologia Animal, Rio de Janeiro, v. 2, p. 83-91, 1959. D?BEREINER, J.; TOKARNIA, C. H. Intoxica??o experimental por Palicourea grandiflora (Rubiaceae) em coelhos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 2, n. 3, p. 121-124, ago./set. 1982. D?BEREINER, J.; TOKARNIA, C. H. Intoxica??o experimental por Arrabidaea japurensis (Bignoniaceae) em coelhos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 3, n. 3, p. 95- 97, 1983. D?BEREINER, J.; TOKARNIA, C. H.; CANELLA, C. F. C. Experimental poisoning of cattle by the pericarp of the fruit of Ricinus communis. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 1, n. 3, p. 95-97, 1981. D?BEREINER, J.; TOKARNIA, C. H.; SILVA, M. F. Intoxica??o por Arrabidaea bilabiata (Bignoniaceae) em bovinos na Regi?o Amaz?nica do Brasil. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 3, n. 1, p. 17-24, 1983. EASON, C. T; GOONERATNE, R ; FITZGERAD, H ; ERIGHT, G ; FRAMPTOM, C. Persistence of sodium monofluoroacetate in livestock animals and risk to humans. Human and Experimental Toxicology, v. 13, p. 119-122, 1994. EASON, C. T; WICKSTROM, M; TUCK, P; WRIGHT, G.R.G. A review of recent regulatory and environmental toxicology studies on 1080: Results and implications. New Zealand Journal of Ecology, v. 23, n. 2, p. 129-137, 1999. EASON, C. Sodium monofluoroacetate (1.080) risk assessment and risk communication. Toxicology, Limerick, v. 181/182, p. 523-530, Dec. 2002. EGEKEZE, J.O.; OEHME, F.W. Inorganic and organic fluoride concentrations in tissues after the oral administration of sodium monofluoroacetate (compound 1080) to rats. Toxicology, v.15, p.43-53, 1979. EGYED, M.N. Mass poisoning in dogs associated with feeding meat contaminated with organofluoride (sodium fluoroacetate or fluoroacetamide). Refu Veterinary, v.35, p.9-11, 1978. 36 EGYED, M.N.; SCHULTZ, R.A. The efficacy of acetamide for the treatment of experimental Dichapetalum cymosum (gibflaar) poisoning in sheep. Onderstepoort Journal of Veterinary Research, v.54, p.231-234, 1986. EISLER, R. Sodium monofluoroacetate (1080) hazards to fish, wildlife, and invertebrates: a synoptic review. Contaminant Hazard Reviews, v.30, february 1995. EPA, U. S. Environmental Protection Agency. Effects of exposure to heavy metals on selected fresh water fish: toxicity of copper, cadmium, chromium, and lead to eggs and fry of seven fish species. Environmental Research Laboratory, Office of Research and Development, Duluth, 1976. 105 p. FELDBERG, W.; KILBY, B. A.; KILBY, M. Report to Director of Research, Ministry of Supply. 1942. ESTRADA, C.; OSMAIDA; CADRELO, T.S.; SALAZAR, A.A.I.; ALMEIDA, S.M.; MONTERO, V. R.; PEILL?N, V. O.; COS, D.Y.; B?RZAGA, R.; CAMPUZANO,Y. Efecto bactericida de la acetamida fur?nica bromada frente a cepas salvajes de Pasteurella multocida in vitro. Revista electr?nica de Veterin?ria. v.8, n.10,p.1695-7504, 2007. FELDWICK, M. G; NOAKES, P.S; PRAUSE, V; MEAD, R.J; KOSTYNIAK, P.J. The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide Gliftor: The potential of 4-methylpyrazole as an antidote. Journal of Biochemical and Molecular Toxicology, v. 12, p. 41-52, 1997. FERNANDES, N. S.; MACRUZ, R. Toxicidade da ?corona? Mascagnia pubiflora (Juss) Griseb. Malpighiaceae em coelhos. Arquivos do Instituto Biol?gico, S?o Paulo, v. 31, n. 1, p. 1-4, 1964. FLAKS, B.; TREVAN, M.T.; FLAKS, A. An electron microscopy study of hepatocellular changes in the rat during chronic treatment with acetamide. Parenchyma, foci and neoplasm. Carcinogenesis, v.4, n.9, p.1117-1125, 1983 FONNUM, F.; JOHNSEN, A.; HASSEL, B. Use of fluorocitrate and fluoroacetate in the study of brain metabolism. Glia, New York, v. 21, n. 1, p. 106-113, Sep. 1997. FOSS, G.L. The toxicology and pharmacology of methyl fluoroacetate (MFA) in animals, with some notes on experimental therapy. Brazilian Journal of Pharmacology, v.3, p.118- 127, 1948. FUYU, G.; HUIFANG, W.; YI, L. Sensitive and selective mTethod for the determination of sodium monofluoroacetate by capillary zone electrophoresis. Journal of Chromatography, v.719, p. 421-426, 1996. GAGNIN, M.A.H.; MARAVALHAS, N. (1969). Ocorr?ncia de alcal?ides no g?nero Palicourea. Anais do 20? Congresso Nacional de Bot?nica, Goi?nia, Goi?s, pp.91-105. GAL, E. M.; PETERS, R. A.; WAKELIN, R. A. Some effects of synthetic fluoro-compounds on the metabolism of acetate and citrate. Biochemistry Journal, v. 64, n. 1, p. 161-168, 1956. 37 GAVA, A.; BARROS, C. S. L. Field observations of Ateleia glazioviana poisoning in cattle in southern Brazil. Veterinary and Human Toxicology, Manhattan, v. 43, p. 37-41, 2001. GAVA, A; BARROS, C.S.L; PILATI, C; BARROS, S.S; MORI, A.M. Intoxica??o por Ateleia glazioviana (Leg. Papilionoideae) em bovinos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 21, p. 49-59, 2001. GAVA, A., STOLF, L., NEVES, D.S., STOLF, O., VARASCHIM, M.S., FERREIRA, F.M.M. Intoxica??o experimental por Prunus sellowii (Rosaceae) em bovinos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 12, n. 1/2, p. 1-4, 1992. GAVA, A; CRISTIANI, J.; BRANCO, J.V; DALMO, S.N; MONDADORI, A.J; SOUZA, R.S. Mortes s?bitas em bovinos causadas pela ingest?o de Mascagnia sp. (Malpighiaceae), no Estado de Santa Catarina. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 18, n. 1, p. 16-20, jan./mar. 1998a. GAVA, A., PILATI, C., CRISTIAN, J., SIM?ES, J., SIM?ES, L. Intoxica??o cianog?nica em bovinos alimentados com Tifton (Cynodon sp.). VIII CAMEV, 8., 1998, Lages. Resumo... Lages:[s. n.], 1998b. GODOY, H. M.; CARMEN, V. M. Myocardial adenine nucleotides, hexose phosphates and inorganic phosphate, and the regulation of phosphofructokinase activity during fluoroacetate poisoning in the rat. Biochemistry Pharmacology, Oxford, v. 23, p. 3179-3189, 1974. GOH, C.S.; HODGSON, D.R.; FEARNSIDE, S.M.; HELLER, J.; MALIKIDES, N. Sodium monofluoroacetate (Compound 1080) poisoning in dogs. Australian Veterinary Journal, v. 83, p. 474-479, 2005. GONCHAROV, N. V.; JENKINS, R. O.; RADILOV, A. S. Toxicology of fluoroacetate: a review, with possible directions for therapy research. Journal of Applied Toxicology, Philadelphia, v. 26, n. 2, p. 148-161, Mar./Apr. 2006. G?RNIAK, S.L.; PALERMO-NETO, J.; SPINOSA, H.S. Effect of CNS depressant drugs on acute intoxication from Palicuorea marcgravii St Hill in rats. Veterinary and Human Toxicology, v.35, p.19-21, 1993. G?RNIAK, S. L.; SOUZA-SPINOSA, H; PALERMO-NETO, J; FERRO, V O; DE OLIVEIRA, F. Chromatographic Isolation of caffeine from Palicourea marcgravii. Veterinary and Human Toxicology, v. 28, n. 6, p. 542, 1986. GRANT, W. M. Toxicology of the eye. 3. ed. Springfield: C. C. Thomas, 1986. 439 p. GREGG, K.; HAMDORF, B.; HENDERSON, K.; KOPECNY, J.; WONG, C. Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning. Applied and Environmental Microbiology, v.64, p.3496-3498, 1998. GRIBBLE, G.W. Fluoroacetate toxicity. Journal of Chemical Education, v.50, p.460-63, 1973. 38 GRUNERT, E. Beobachtungen ?ber Schlangenbissverletzungen bei grossen Haustieren in S?d-Brasilien. Deutsche Tier?rztliche Wochenschrift, Hannover, v. 74, n. 20, p. 531-532, 1967. GUIMAR?ES, C. C. Herva de rato. Vida M?dica, Rio de Janeiro, v. 2, p. 324-333, 1934. HARAGUCHI, M. Plantas T?xicas de Interesse na Pecu?ria. Biol?gico, S?o Paulo, v.65, n.1/2, p.37-39, jan./dez., 2003. HAYES, W.J.; LAWS, E.R. Handbook of Pesticide Toxicology. [S. l.]: Academic. 1991. 3 v. HELAYEL, M.A. Morte s?bita em bovinos causada pela ingest?o de Pseudocalymma elegans (Bignoniaceae) no munic?pio de Rio Bonito, RJ. Rio de Janeiro, 2008. 91p. Disserta??o (Mestrado em Medicina Veterin?ria) ? Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro. HENRICI, M. Preliminary report upon the occurrence of hydrocyanic acid in the grasses of Bechuanaland: part I. 11th and 12th Rep. Director Veterinary Education Research, Pretoria, p. 495-498, 1926. HOEHNE, F. C. Plantas t?xicas e suspeitas da Flora Brasilica: Palicourea marcgravii St. Hil. (Psychotria marcgravii Spreng.) herva de rato verdadeira. Revista Ind?stria Animal, S?o Paulo, v. 2, n. 8, p. 873-881, 1932. HOLLIS, J.M.; LOVAS, F.J.; REMIJAN, A.J.; JEWELL, P.R.; ILYUSHIN, V.V.; KLEINER, I. Detection of acetamide (CH3CONH2): the largest interstellar molecule with a peptide bond. The Astrophysical Journal, v.643, n.1, p.25?28, 2006. HOOGENBOOM, J.J.L.; RAMMELL, C.G. Determination of sodium monofluoroacetate (compound 1080) in tissues and baits as its benzyl ester by reaction-capillary gas chromatography. Journal of Analytical Toxicology, v.11, p.140-143, 1987. HOPPER, S. D. Poison peas: deadly protectors. Landscope, [S. l.], v. 6, n. 4, p. 45-50, 1991. HORNSHAW, T. C.; RINGER, R. K.; AULERICH, R. J.; CASPER, H. H. Toxicity of sodium monofluoroacetate (compound 1080) to mink and European ferrets. Environmental Toxicology and Chemistry, v.5, p.213-223, 1986. HUANG, T.Y.; PANG, X.Q.; CH`ANG, H.L. Prophylactic effect of reserpine in cardiac failure caused by monofluoroacetic acid derivatives. Acta of Pharmacology and Toxicology, v.47, p.78-80, 1980. HUTCHENS, J.O.; WAGNER, H.; PODOLSKY, B. The effect of ethanol and various metabolites on fluoroacetate poisoning. Journal of Pharmacology and Experimental Therapeutic, v.95, p.62-70, 1949. JABOUR, F. F ; SEXAS, J.N ; TOKARNIA, C.H ; BRITO, M.F. Varia??o da toxidez de Arrabidaea bilabiata (Bignoniaceae) Em resposta a: coelhos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 26, n. 3, p. 171-176, jul./set. 2006. 39 JENSEN, R. J.; TOBISKA, J. W.; WARD, J. C. Sodium fluoroacetate (compound 1.080) poisoning in sheep. Journal of Veterinary Research, [S. l.], v. 9, p. 370-378, 1948. JONES, T. C.; HUNT, R. D.; KING, N. W. Patologia Veterin?ria. 6? ed. S?o Paulo: Manole, 2000. 1415 p. JUBB, K. V. F.; KENNEDY, P. C.; PALMER, N. Pathology of Domestic Animals, 5. ed, Toronto: Saunders elsevier, 2007. 737 p. v. 3. KELLERMAN, T.S. ; COETZER, J.A.W. ; NAUDE, T.W. ; BOTHA, C.J. Plant Poisonings and Mycotoxicoses. Oxford University Press, Cape Town, RSA, 2005. p.310. KEMMERLING, W. Toxicity of Palicourea marcgravii: combined effects of fluoroacetate, N-methyltyramine and 2-methyltetrahydro-beta-carboline. Zeitschrift f?r Naturforschung, T?bingen, v. 51, n. 1/2, p. 59-64, 1996. KIMBALL, B.A.; MISHALANIE, E.A. Gas chromatographic determination of sodium monofluoroacetate as the free acid in an aqueous solvent. Journal of Chromatography, v.634, p.289-296, 1993. KRAMER, H.L. Liquid chromatographic determination of sodium fluoroacetate (compound 1080) in meat baits and formulations. Journal of Association Off Analytical Chemistry, v. 67, n.6, p. 1058-61, 1984. KREBS, H.C.; KEMMERLING, W.; HABERMEHL, G. Qualitative and quantitative determination of fluoroacetic acid in Arrabidea bilabiata and Palicourea marcgravii by FNMR spectroscopy. Toxicol, v.32, p.909-913, 1994. LANGENEGGER, J. Ocorr?ncia do carb?nculo hem?tico em animais no Brasil. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 14, n.4, p.135-136, out./dez. 1994. LEFEBVRE, P.W.; HOLLER, N.R.; MATTESON, R.E., SCHAFER JR., EDWARD W.; CUNNINGHAM, D.J. Developmental status of N-(3-chloro-4-methylphenyl). Acetamide as a candidate blackbird/starling roost toxicant. Wildlife Damage Management, Internet center for bird control seminars proceedings, University of Nebraska ? Lincoln, v. 8, p. 65-68, 1979. LIU, D.; ZHANG, L. Structure and Properties of Soy Protein Plastics Plasticized with Acetamide. Macromolecular Materials and Engineering, n.291, p.820-828, 2006. LOYD, W.E. Sodium fluoroacetate (compound 1080) poisoning. In: KIRK, R. W. et.al. Current Veterinary Therapy. 8.ed. Philadelphia: W.B. Saunders,1983. p. 112-3. MARAIS, J. C. S. Monofluoroacetic acid, the toxic principle of ?gifblaar? Dichapetalum cymosum. Onderstepoort Journal of Veterinary Science, Pretoria, v. 20, p. 67, 1944. MARQUES, A.P.; RIET-CORREA, F.; SOARES, M.P.; ORTOLANI, E.L.; GIULIODORI, M.J. Mortes s?bitas em bovinos associadas ? car?ncia de cobre. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 23, n. 1, p. 21-32, jan./mar. 2003. 40 MARRAZZI, M.A.; HOLLIDAY, J.F. Comparison of insulin hypoglycemia-induced and fluoroacetate-induced convulsions in gold thioglucose lesioned mice. Biochemistry and Pharmacology, v.30, p.3231-3237, 1981. McGARY, E.D.; MELOAN, C.E. A rapid qualitative method for the detection of monofluoroacetic acid (1080) in the presence of sodium fluoride in liquide baits. Analytical Letter, v.15, p. 1051-1056, 1982. McGIRR, J. L.; PAPWORTH, D. S. The toxicity of rodenticides: I Sodium fluoroacetate, Antu and Warfarin. The Veterinary Record, v. 67, p. 124-131, 1955. McILROY, J. C. The sensitivity of Australian animals to 1080 poison. III. Marsupial and eutherian herbivores. Australian Wildlife Research, v. 9, p. 487-503 1982a. McILROY J. C. The sensitivity of Australian animals to 1080 poison IV. Native and introduced rodents. Australian Wildlife Research, v. 9, p. 505-517, 1982b. McILROY J. C. The sensitivity of Australian carnivorous mammals to 1080 poison. In: ARCHER, M. Carnivorous Marsupials. Australia: Royal Zoological Society of NSW, 1982c. p 267-271. MCLLROY, J. C. The effect on Australian animals of 1080-poisoning campaigns. In: VERTEBRATE PEST CONFERENCE, 15., 1992. Proceedings? University of Nebraska: Lincon, 1992. p.355-359. MCTAGGART, D. R. Poisoning due sodium fluoroacetate (?1.080?). The Medical Journal of Australian, Sydney, v. 2, n. 14, p. 641-642, Oct. 1970. MEHLMAN, M. A. Inhibition of pyruvate carboxylation by fluorocitrate in rat kidney mitochondria. The Journal of Biological Chemistry, Baltimore, v. 243, n. 8, p. 1919-1925, Abr. 1968. MELLO, E. M. M.; FERNANDES, J. S. Contribui??o ao estudo de plantas t?xicas brasileiras. Servi?o de Informa??o Agr?cola: Minist?rio da Agricultura, Rio de Janeiro, 1941. N?o paginado. MINNAAR, P.P.; SWAN, G.E.; McCRINDLE, R.I.; DE BEER, W.H.; NAUDE, T.W. A high-performance liquid chromatographic method for the determination of monofluoroacetate. Journal of Chromatography and Science, v. 38, p.16-20, 2000. MORAES, R. L. Comprova??o qu?mica e biol?gica da presen?a de monofluoroacetato nas folhas de Palicourea marcgravii St. Hil. 1993. 83 f. Tese (Doutorado em Toxicologia) - Universidade de S?o Paulo, 1993. MOUNT, M.E. Toxicologia. In: ETTINGER, S.J.,ACKERMAN, N.,ALTMAN, S. et al. Tratado de medicina interna veterin?ria. 3.ed.S?o Paulo: Manole, 1992. p. 482-8. NIETO, O. Z. Fichas t?cnicas de plaguicidas a prohibir o restringir incluidos en el acuerdo N? 9 de La XVI Reuni?n del Sector Salud de Centroam?rica y Rep?blica Dominicana (RESSCAD), Costa Rica: Organiza??o Mundial da Sa?de, 2001. 255p. 41 NOBEGA Jr, J.E., RIET-CORREIA, F., MEDEIROOS, R.M.T., DANTAS A.F.M. Intoxica??o por Sorhgum halepense (Poaceae) em bovinos no semi-?rido. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 26, n. 4, p. 201-204, out./dez. 2006. NOGUEIRA, V.A.; FRAN?A, T.N.; PEIXOTO, T.C.; CALDAS, S.A.; ARMI?N, A.G.; PEIXOTO P. 2010. Intoxica??o experimental por monofluoroacetato de s?dio em bovinos: aspectos cl?nicos e patol?gicos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 30, n. 7, p. 533-540, 2010. NORRIS, W. R.; EASON, C. T.; WICKSTROM, M. L. Sorption of fluoroacetate (Compound 1080) by colestipol, activated charcoal and anion-exchange resins in vitro and gastrointestinal decontamination in rats. Veterinary and Human Toxicology, v. 42, p. 269-275, 2000. NOV?K, L., MISUSTOV?, J., HOSEK, B. Course of respiratory exchange and body temperature in mice after repeated administration of fluoracetate: an indicator of aconitase activity in vivo. Physiology Bohemoslov, v.21, p.53-61, 1972. OBERHOFER, T.R.; ROWEN, J.W.; HIGBEE, J.W.; JOHNS, R.W. Acetamide Agar for Differentiation of Nonfermentative Bacteria. Applied Environmental Microbiology, v.28, n.4, p.720-721, 1974. O?HAGAN, B. J. Fluoroacetate poisoning in seven domestic dogs. Australian Veterinary Journal, Sydney, v. 82, n. 12, p. 756-758, Dec. 2004. OLIVEIRA, C.M.C.; BARBOSA, J.D.; MACEDO, R.S.C.; BRITO, M.F.; PEIXOTO, P.V.; TOKARNIA, C.H. Estudo comparativo da toxidez de Palicourea juruana (Rubiaceae) para b?falos e bovinos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 24, n. 1, p. 27-30, jan./mar. 2004. OLIVEIRA, M. M. Chromatographic isolation of monofluoroacetic acid from Palicourea marcgravii St. Hil. Experientia, Basel, v. 19, n. 11, p. 586-587, Nov. 1963. OLIVEIRA, Z. Sensibilidade dos roedores aos novos rodenticidas. Revista de higiene e sa?de p?blica, v. 14, n. 1/2, p. 45-56, 1955. OMARA, F.; SISODIA, C.S. Evaluation of potential antidotes for sodium fluoroacetate in mice. Veterinary and Human Toxicology, Manhattan, v. 32, n. 5, p. 427-431, 1990. OMS. Fichas t?cnicas de plaguicidas a prohibir o restringir incluidos en el acuerdo N? 9 de La XVI Reuni?n del Sector Salud de Centroam?rica y Rep?blica Dominicana (RESSCAD), Costa Rica, julho 2001. ORTIS, M. Comiss?o externa destinada a acompanhar as investiga??es sobre o envenenamento de animais ocorrido na Funda??o Zool?gico de S?o Paulo (envenenamento no Zool?gico de S?o Paulo). 2005. Dispon?vel em www.camara.gov.br/sileg/integras/292702.pdf. Acesso em 29.03.08. OSWEILER,G.D. Rodenticides. In: Toxicology. Media: Willians & Wilkins, 1996. chap. 22, p. 289-93. 42 OZAWA, H.; TSUKIOKA, T. Determination of sodium monofluoroacetate in soil and biological samples as the dichloroanilide derivative. Journal of Chromatography, v. 473, p. 251-259,1989. PACHECO, G.; CARNEIRO V. Estudos experimentais sobre plantas t?xicas. I.Intoxica??o dos animais pela ?erva-de-rato da mata?. Revista Sociedade Paulista Medicina Veterin?ria, S?o Paulo, v. 2, n. 2/3, p. 23-46, 1932. PALERMO-NETO, J., MORAES-MOREAU, R.L. Monofluoroacetato de s?dio (Composto 1080). Folha Medica, v. 110, p. 59-65, 1995. PALMATEER, S. D. 1989. Status of strychnine, compound 1080, and registered alternatives. Pages 14-16 in Ninth Great Plains Wildlife Damage Control Workshop proceedings. U.S. Department of Agriculture Forest Service General Technical Report RM-171 (also published as Great Plains Agricultural Council Publication 127). PALMATEER, S. D. 1990. Registration status of vertebrate pesticides with emphasis on 1080 and strychnine. Pages 113-115 in L. R. Davis and R. E. Marsh, editors. Proceedings 14th Vertebrate Pest Conference. University of California, Davis. PARTON, K. Sodium monofluoroacetate (1080). In: Small Animal Toxicology, Philadelphia: Saunders, 2006. p. 1055-1062. PARTON, K.; BRUERE, A. N.; CHAMBERS, J. P. Fluoroacetate-1080. Veterinary Clinical Toxicology, v. 208, p. 141-153, 2001. PATTISON F. L. Toxic aliphatic fluorine compounds. London: Elsevier Publishing, 1959. 227 p. PASSOS, D. A. Intoxica??o experimental em caprinos (Capra hircus) por Palicourea aeneofusca (M. Arg.) Standl (Rubiaceae). 1983. 40 p. Disserta??o (Mestrado em Ci?ncia Veterin?ria) - Universidade Federal Rural de Pernambuco, Recife, 1983 PEACOCK, E. A. 1964. Sodium monofluoroacetate (compound 1080). U.S. Bureau of Sport Fisheries and Wildlife, Division of Predator and Rodent Control, Circular Letter dated 1 July 1964. Mimeographed. 26 pp. PECKOLT, T, Apud GUIMAR?ES, C.C. (1934). Herva de rato. Vida M?dica, Rio de Janeiro, v.2, p.324-333, 1868. PEIXOTO, P. V.; DOBEREIBER, J.; TOKARNIA, C.H.; PEIXOTO, C.S.. Intoxica??o experimental por Palicourea marcgravii (Rubiaceae) em coelhos. Pesquisa Veterin?ria Brasileira, Serop?dica, v. 7, n. 4, p. 117-129, jul./set. 1987. PEIXOTO, P.V.; NOGUEIRA, V.A.; FRAN?A, T.N.; PEIXOTO, T.C.;, D?BEREINER, J.; TOKARNIA, C.H. 2011a. Relationship between a peculiar form of hydropic-vacuolar degeneration of the distal convoluted tubules, monofluoroacetate poisoning, and plants that cause ?sudden death? in Brazil, p.365-372. In: Riet-Correa F., Pfister J., Schild A.L. & Wierenga T. (Eds), Poisoning by Plants, Mycotoxins, and related Toxins. CABI, London. 43 PEIXOTO, T.C.; NOGUEIRA, V.A.; CALDAS, S.A.; FRAN?A, T.N.; PEIXOTO P.V. 2011b. Efeito protetor da acetamida em bovinos indica ?cido monofluoroac?tico como princ?pio t?xico de Palicourea marcgravii. (Submetido para publica??o) PEIXOTO, T.C.; CALDAS, S.A.; IGLESIAS, L.; CATUNDA JUNIOR, F.E.A.; FRAN?A, T.N.; PEIXOTO, P.V. 2011c. Efeito protetor da acetamida sobre a intoxica??o experimental por monofluoroacetato de s?dio e plantas que causam morte s?bita em ratos. (Submetido para publica??o) PEIXOTO, T.C; NOGUEIRA, V.A.; COELHO, C.D.; VEIGA, C.C.P.; PEIXOTO, P.V.; BRITO M.F. Aspectos cl?nico-patol?gicos e laboratoriais da intoxica??o experimental por monofluoroacetato de s?dio em ovinos. Pesquisa Veterin?ria. Brasileira, Serop?dica, v. 30, n. 12, p.1021-1030, 2010d. PEREIRA, N. A.; PEREIRA, S. M. N. Contribui??o ao estudo de plantas t?xicas e seus antagonistas: erva-de-rato, a Rubiaceae, Palicourea marcgravii. Revista Brasileira de Farm?cia, v. 86, n. 3, p. 109-11, 2005. PETERS, R. A. Lethal synthesis. Proceedings of the Royal Society of London. Series B, Biological Sciences, v. 139, n. 895, p. 143-170, 1952. PETERS, R.A.; SPENCER, H.; BIDSTRUP, M.D. Subacute fluoroacetate poisoning. Journal of Occupational Medicine, v. 23, n. 2, p.112-113, 1981. PONTUAL, K. A. Q. Caracteriza??o do princ?pio t?xico de Palicourea marcgravii St. H |
Page generated in 0.005 seconds