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Previous issue date: 2015-07-31 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / The gene encoding myostatin (MSTN), located on chromosome 18 (ECA 18) and the SNP
BIEC2-808543 located in the intergenic region, which precedes the gene encoding the protein
similar to the nuclear corepressor receptor dependent binder (LCORL), located on chromosome
3 (ACE 3) in horses, both positioned in regions that are associated with conformational traits
of these animals. In view of this, we aimed to identify if the variations described in MSTN and
LCORL loci exist in the study population; and to identify the effects of these polymorphisms
on the growth profiles of these animals. For this purpose, the characteristics measured were
weight, height at withers and hip height of foals at different ages, belonging to the Coudelaria
e Campo de Instru??o de Rinc?o do Ex?rcito Brasileiro. Nonlinear mixed models were adjusted
resulting from the combination of six nonlinear simple models, Brody (1945), Gompertz
(Winsor, 1932), Logistics (Ratkowski, 1983), Von Bertalanffy (1957), generalized Michaelis-
Menten (Lopez et al., 2000) and Richards (1959) associated with four types of variance
functions for each model, homogeneous, exponential, asymptotic and staggered. The
polymorphism described in the promoter region of the MSTN gene was not found in the studied
population, in which there has been only the T allele, however the BIEC2-808543
polymorphism, located in the region prior to the LCORL gene is significantly associated (P <0,
05) to the characteristics evaluated, in which the animals who presented the genotype TT were
smaller and lighter when compared to the other genotypes. There was no significant difference
between animals with CT and CC genotype. The model that best describes the growth curve for
body mass variance is the model of Brody (1945) associated with the scaled variance for the
variable height at the withers the model that best fit was the Von Bertalanffy (1957) (adjusted
without polymorphism effect in b) parameter associated with the asymptotic variance and the
characteristic hip height the model that best described was that of Brody (1945) associated with
the asymptotic variance, explaining that the nonlinear mixed models are indeed promising to
describe equine growth curves, for the simple models did not differ much among themselves
what defined in fact the selection of the model was the variance, being for body mass staggered
variance and the height at the withers and on the back, the asymptotic variance. This
polymorphism can be used as molecular markers for early selection of foals as to the
characteristics evaluated / O gene que codifica a miostatina (MSTN), localizado no cromossomo 18 (ECA 18) e o SNP
BIEC2-808543 localizado na regi?o interg?nica que antecede o gene que codifica a prote?na
semelhante a correpressor de receptor nuclear dependente de ligante (LCORL), localizado no
cromossomo 3 (ECA 3) de cavalos, ambos posicionados em regi?es que est?o associadas ?s
caracter?sticas conformacionais destes animais. Diante disto, objetivamos identificar se as
varia??es descritas nos loci MSTN e LCORL, existem na popula??o em estudo; al?m de verificar
os efeitos desses polimorfismos sobre os perfis de crescimento desses animais. Com este intuito
foram mensuradas as caracter?sticas massa corporal, altura na cernelha e altura na garupa de
potros em diversas faixas et?rias, pertencentes ? Coudelaria e Campo de Instru??o de Rinc?o
do Ex?rcito Brasileiro. Foram ajustados modelos n?o lineares mistos que resultaram da
combina??o de seis modelos n?o lineares simples, Brody (1945), Gompertz (Winsor, 1932),
Log?stico (Ratkowski, 1983), Von Bertalanffy (1957), Michaelis-Menten generalizado (L?pez
et al., 2000) e Richards (1959), associados a quatro tipos de fun??es de vari?ncia para cada
modelo, homog?nea, exponencial, assint?tica e escalonada. O polimorfismo descrito na regi?o
promotora do gene MSTN n?o foi encontrado na popula??o estudada, na qual observa-se apenas
o alelo T, entretanto o polimorfismo BIEC2-808543, localizado na regi?o que antecede o gene
LCORL, est? significativamente associado (P<0,05) ?s caracter?sticas avaliadas, sendo os
animais que apresentaram o gen?tipo TT menores e mais leves quando comparado com os
demais gen?tipos. N?o foi observada diferen?a significativa entre os animais com gen?tipo TC
e CC. O modelo que melhor descreve a curva de crescimento para a vari?vel massa corporal ?
o modelo de Brody (1945) associado com a vari?ncia escalonada, para a vari?vel altura na
cernelha o modelo que melhor se ajustou foi o de Von Bertalanffy (1957) (ajustado sem efeito
de polimorfismo no par?metro b) associado com a vari?ncia assint?tica e para a caracter?stica
altura na garupa o modelo que melhor a descreveu foi o de Brody (1945) associado ? vari?ncia
assint?tica, elucidando que os modelos n?o-lineares mistos s?o de fato promissores para a
descri??o de curvas de crescimento de equinos, pois os modelos simples n?o diferiram muito
entre si o que definiu de fato a sele??o do modelo foi a vari?ncia, sendo para massa corporal a
vari?ncia escalonada e para as alturas, na cernelha e na garupa, a vari?ncia assint?tica. Este
polimorfismo pode ser utilizado como marcador molecular para sele??o precoce de potros
quanto ?s caracter?sticas avaliadas
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1392 |
| Date | 31 July 2015 |
| Creators | Costa, ?rica Cristina Xisto da |
| Contributors | Soares, Maria Am?lia Menck, Melo, Ana L?cia Puerro de, Vieira, Ricardo Augusto Mendon?a, Gl?ria, Leonardo Siqueira |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Zootecnia, UFRRJ, Brasil, Instituto de Zootecnia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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