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Previous issue date: 2017-04-27 / CAPES / Prebiotics, such as lactulosis, may favor the switch on the fermentative pattern of the colonic microbiota from proteolytic to saccharolytic, which allows bigger assimilation of nitrogenous compounds by the microrganisms of the colon. The present study aimed to evaluate, in dogs with CKD, the effect of the continued orally use of lactulosis over the nitrogenous compounds metabolisms?, the iron metabolism and on serum levels of albumin, magnesium, calcium and phosphorus. Twenty-one animals with CKD in IRIS II and III stages, under normal handling and feeding, were clinically and laboratorially evaluated by a 28 days period; divided in three groups according to treatment: T1 ? lactulosis + therapeutic diet, T2 ? lactulosis + standard treatment + therapeutic diet, T3 ? standard treatment + therapeutic diet . For the three groups (T1, T2 and T3), clinical parameters indicated anaemia and body score from regular to bad, according to the disease?s degree, during the hole treatment. The haematological and biochemical?s averages are consistent with common laboratorial findings in nephrophatic patients, with high levels of urea and creatinine; and low leves of haematocrit. For all the evaluated parameters in this study, the averages? variations during the period didn?t show any significant difference between times and treatments, with the exception of the calcemia averages that were greater for T1 group; which may indicate that for this animals? group the monotherapy with lactulosis could have increased the absorption of this mineral in those patients. With regard to iron metabolism, this study?s data revealed that the anaemia found in the dogs throughout the experimental period presented chronicity features, since the groups? means remained within the iron and transferrin references, besides high ferritin averages, without significant differences between groups and moments. The obtained data allowed to conclude that there was no difference between the proposed treatments in relation to clinical state and the biochemical and mineral profiles, such as iron metabolism; which justifies that the action mechanisms of prebiotics in nephrophatic patients should be evaluated with more details. / Prebi?ticos, como a lactulose, podem favorecer a altera??o do padr?o fermentativo da microbiota col?nica de proteol?tico para sacarol?tico; o que possibilita maior assimila??o de compostos nitrogenados pelos microrganismos do c?lon. O presente estudo teve por objetivo avaliar, em c?es com DRC, o efeito da utiliza??o continuada de lactulose por via oral, sobre o metabolismo de compostos nitrogenados; o metabolismo do ferro, e sobre as concentra??es s?ricas de albumina, magn?sio, c?lcio e f?sforo. Vinte e um animais portadores de DRC em est?gios IRIS II e III, com manejo e alimenta??o normais, foram avaliados clinicamente e laboratorialmente por um per?odo de 28 dias; divididos em tr?s grupos conforme o tratamento: T1 ? lactulose + ra??o terap?utica, T2 ? lactulose + tratamento convencional + ra??o terap?utica, T3 ? tratamento convencional + ra??o terap?utica. Para os tr?s grupos (T1, T2 e T3), os par?metros cl?nicos foram indicativos de anemia e escore corporal de regular a ruim, de acordo com o grau da enfermidade, ao longo de todo tratamento. As m?dias dos par?metros hematol?gicos e bioqu?micos s?o condizentes com achados laboratoriais comuns em nefropatas; com elevados valores de ureia e creatinina e valores decrescidos de hemat?crito. Para todos os par?metros as varia??es durante o per?odo n?o apresentaram diferen?a significativa entre os tempos e tratamentos, ? exce??o das m?dias de calcemia que foram maiores para o grupo T1; o que pode indicar que para os animais deste grupo a monoterapia com lactulose pode ter aumentado a absor??o deste mineral. Com rela??o ao metabolismo de ferro, os dados revelaram que a anemia encontrada nos c?es em todo o per?odo experimental apresentou caracter?sticas de cronicidade, uma vez que as m?dias dos grupos permaneceram dentro dos intervalos de refer?ncia para ferro e transferrina; al?m de m?dias elevadas de ferritina, sem diferen?as significativas entre grupos e momentos. Os dados obtidos permitiram concluir que n?o houve diferen?a entre os tratamentos propostos com rela??o ao estado cl?nico e aos perfis bioqu?micos e minerais, bem como ao metabolismo de ferro; o que justifica que os mecanismos de a??o dos prebi?ticos em nefropatas devem ser avaliados com maiores detalhes.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/2227 |
| Date | 27 April 2017 |
| Creators | PEREIRA, Juliana de Abreu |
| Contributors | Botteon, Rita de C?ssia Campbell Machado, Botteon, Rita de C?ssia Campbell Machado, Veado, J?lio C?sar Cambraia, Machado, Carlos Henrique, Nobre e Castro, Maria Cristina, Baldani, Cristiane Divan |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas), UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | ABENSUR, H. Defici?ncia de ferro na doen?a renal cr?nica. Revista Brasileira de Hematologia e Hemoterapia, v.32, supl. 2, p.84-88, 2010. ADAMS, L. G. Falla Renal Cronica ? Enfermidades y Sindromes Clinicos. In: The 5 minutes veterinary consult. Baltimore: Willians & Wilkins, 1997. p.644-645. AL SIBAE, M.R.; MCGUIRE, B.M. Current trends in the treatment of hepatic encephalopathy. Therapeutics and Clinical Risk Management, v.5, p.617-626, 2009. AL-BADR, W.; MARTIN, K.J. Vitamin D and kidney diseases. Clinical Journal of the American Society Nephrology, v. 208, n.3, p.1555-1560, 2008. ALMEIDA, D.C.; PEREIRA, C.S.; GRANJEIRO, J.M.; MACHADO, W.A.S.; TOSTES, F.R.V.; BARBOZA, E.S.P.A rela??o bidirecional entre doen?a periodontal e doen?a renal cr?nica: da progress?o da doen?a renal cr?nica ? terapia renal substitutiva de di?lise. Revista de Periodontia, v.21, p.73-79, 2011. ALMEIDA, Jr. B.R.; RODRIGUES, R.L. Influ?ncia da atividade f?sica e da ingest?o de c?lcio na osteoporose. Motriz, v.3, p.50?55, 1997. ANDRESS, D. L. Vitamin D in chronic kidney disease: a systemic role for selective vitamin receptor activation. Kidney International, v.69, p.33-43, 2006. ANDREWS, N. C. A genetic view of iron homeostasis. In: Seminars in hematology. WB Saunders, v. 39, n. 4, p. 227-234, 2002. ANTUNES, M. S. Pesquisa Cl?nica e Etiol?gica da Anemia em C?es (Canis familiaris). Disserta??o (Mestrado em Medicina Veterin?ria). Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2009. 75p. ARIOLI, E. L.; CORR?A, P.H.S. Hipocalcemia. Arquivos Brasileiros de Endocrinologia e Metabologia, v.43, p.467?471, 1999. ARONOV, P.A.; LUO, F. J.; PLUMMER, N. S.; QUAN, Z.; HOLMES, S.; HOSTETTER, T. H.; MEYER, T. W. Colonic contribution to uremic solutes. Journal of the American Society of Nephrology, v.22, p.1769-1776, 2011. ASIF, M. The impact of dietary fat and polyunsaturated fatty acids on chronic renal diseases. Current Science Perspectives, v.1, n. 2, p.51-61, 2015. ?VILA, K. M.; JOVINO, P.L.; FERREIRA, P.C.C. Emerg?ncia do trato urin?rio. In: SANTOS, M. M.; FRAGATA, F. S. Emerg?ncia e Terapia Intensiva Veterin?ria em Pequenos Animais. Editora Roca, S?o Paulo, 2008, p.438 - 446. BACIC, A. KOGIKA, M.N.; BARBARO, K.C.; IUAMOTO, C.S.; SIM?ES, D.M.; SANTORO, M.L. Evaluation of albuminuria and its relationship with blood pressure in dogs with chronic kidney disease. Veterinary Clinical Pathology, v.39, n.2, p.203-209, 2010. BADIEE, A. H. Lactulose for reduction of nitrogen products in patients with chronic kidney disease. BARA, M.; GUIET-BARA, A.; DURLACH, J. A qualitative theory of the screening-binding effects of magnesium salts on epithelial cell membranes: A new hypothesis. Magnesium Research, v.2, p.243-248, 1989. BAMMENS, B.; VERBEKE, K.; VANRENTERGHEM, Y.; EVENEPOEL, P. Evidence for impaired assimilation of protein in chronic renal failure. Kidney International, v.64, p.2196-2203, 2003. BAMMENS, B.; EVENEPOEL, P.; KEULEERS, H.; VERBEKE, K.; VANRENTERGHEM, Y. Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney International, v.69, p.1081-1087, 2006. BARA, M.; GUIET-BARA, A.; DURLACH, J. Modification of human amniotic membrane stability after addition of magnesium salts. Magnesium Research, v.1, p.23-27, 1988. BARBAGALLO, M.; DOMINGUEZ, L.J. Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Archives of Biochemistry and Biophysics, v.458, n. 1, p.40-47, 2007. BARBAGALLO, M.; DOMINGUEZ, L.J.; GALIOTO, A.; PINEO, A.; BELVEDERE, M. Oral magnesium supplementation improves vascular function in elderly diabetic patients. Magnesium Research, v.23, n. 3, p.131-137, 2003. BARRETO, F. C.; BARRETO, D. V.; LIABEUF, S.; MEERT, N.; GLORIEUX, G.; TEMMAR, M.; CHOUKROUN, G.; VANHOLDER, R.; MASSY, Z. A. Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clinical Journal of the American Society of Nephrology, v.4, p.1551-1558, 2009. BARTLETT, P.C.; VANBUREN, J. W.; BARTLETT, A. D.; ZHOU, C. Case-Control Study of Risk Factors Associated with Feline and Canine Chronic Kidney Disease. Veterinary Medicine International, v.2010, p.1-9, 2011. BATISTA, D. G. Dieta com Sobrecarga de C?lcio e F?sforo Leva a Diminui??o do Volume ?sseo de Ratos Ur?micos. 2? edi??o. S?o Paulo: Servi?os de Biblioteca e Documenta??o; 2005. BEARD, J.L.; DAWSON, H.; PI?ERO, D.J. Iron metabolism: a comprehensive review. Nutrition Reviews, v.54, p.295-317, 1996. BEAUMONT, C.; VAILONT, S. Iron homeostasis. In: BEAUMONT, C.; BERIS, P.; BEUZARD, Y; BRUGNARA, C. Disorders of iron homeostasis, erythrocytes, erythropoiesis. Genova, Italy: Forum Service Editore; 2006, p.393-406. BELOSHAPKA, A.N., DOWD, S.E., SUCHODOLSKI, J.S., STEINER, J.M., DUCLOS, L., SWANSON, K.S. Fecal microbial communities of healthy adult dogs fed raw meat-based diets with or without inulin or yeast cell wall extracts as assessed by 454 pyrosequencing. FEMS Microbiology Ecology, v.84, p.532-541, 2013. BENNO, Y., MITSUOKA, T. Effect of advances in age on intestinal microflora of beagle dogs. Microecology and Therapy, v.19, p.85-91, 1989. BENNO, Y., NAKAO, H., UCHIDA, K., MITSUOKA, T. Impact of the advances in age on the gastrointestinal microflora of beagle dogs. The Journal of Veterinay Medical Science, v.54, p.730-706, 1992. BERGEN, W.G.; WU, G. Intestinal nitrogen recycling and utilization in health and disease. Journal of nutrition, v.12, p.1-5, 2009. BERGWITZ, C.; JUPPNER, H. Regulation of phosphate homeostasis by PTH, vitamin D and FGF-23. Annual Review Medicine, v.61, p.91?104, 2010. BESARAB, A.; AMIN, N.; AHSAN, M.; VOGEL, S. E.; ZAZUWA, G.; FRINAK, S.; ZAZRA, J. J.; ANANDAN, J. V.; GUPTA, A. Optimization of epoetin therapy with intravenous iron therapy in hemodialysis patients. Journal of the American Society of Nephrology, v.11, n. 3, p.530-538, 2000. BEYNEN, A. C.; KAPPERT, H. J.; YU, S. Dietary lactulose decreases apparent nitrogen absorption and increases apparent calcium and magnesium absorption in healthy dogs. Journal of Animal Physiology and Animal Nutrition, v.85, p.67-72, 2001. BICHARD, S. J.; SHERDING, R. G. Cl?nica de pequenos animais. 2? edi??o, Editora Roca, S?o Paulo, 2003, p.1001-1008. BIRKETT, A.; MUIR, J.; PHILLIPS, J.; JONES, G.; O'DEA K. Resistant starch lowers fecal concentrations of ammonia and phenols in humans. American Journal of Clinical Nutrition, v.63, p.766-772, 1996. BOEHM, G; MORO, G. Structural and functional aspects of prebiotics used in infant nutrition. Journal of Nutrition, v.138, p.1818?1828, 2008. BOELAERT, J. R.; DANEELS, R. F.; SCHURGERS, M. L.; MATTHYS, E. G.; GORDTS, B. Z.; VAN LANDUYT, H. W. Iron overload in haemodialysis patients increases the risk of bacteraemia: a prospective study. Nephrology Dialysis Transplantation, v.5, n. 2, p.130-134, 1990. BRONNER, F. Recent developments in intestinal calcium absorption. Nutrition Reviews, v.67, p.109?113, 2009. BROVIDA, C. et al. Diagn?stico Precoce da Insufici?ncia Renal Cr?nica. Revista Foccus; ed. Especial. Royal Canin (Waltham), 2004. BROWN, S. A. CROWELL, W.A.; BROWN, C.A.; BARSANTI, J.A.; FINCO, D.R. Pathophysiology and Management of Progressive Renal Disease The Veterinary Journal, n.154, p.93-109, 1997. BROWN, S. A. Evaluation of chronic renal disease: A staged approach. Compendium on Continuing Education for the Practicing Veterinarian, v.21, p.752, 1999. BROWN, S. A.; CROWELL, W. A.; BARSANTI, J. A.; WHITE J. V.; FINCO, D. R. Beneficial effects of dietary mineral restriction in dogs with marked reduction of functional renal mass. Journal of the American Society of Nephrology, v.1, p.1169-1179, 1991. BROWN, S. A.; RICKERTSEN, M.; SHELDON, S. Effects of an intestinal phosphate binder on serum phosphate and parathyroid hormone concentration in cats with reduced renal function. Journal of Applied Research in Veterinary Medicine, v.6, n. 3, p.155?160, 2008. BROWN, S.A. Diagn?stico y tratamiento de la insufici?ncia renal cr?nica em perros. Revista Walthan Focus: Est?dio Del Tracto urin?rio, Edicion especial, p.14-17, 2002. BROWN, S., ATKINS, C., BAGLEY, R., CARR, A., COWGILL, L., DAVIDSON, M.; EGNER, B.; ELLIOT, J.; HENIK, R.; LABATO, M.; LITTMAN, M.; POLZIN, D.; ROSS, L.; SNYDER, P.; STEPIEN, R. Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. Journal of Veterinary Internal Medicine, v. 21, n. 3, p. 542-558, 2007. BROWN, S.A., BROWN, C.A., CROWELL, W.A et al. Effects of dietary polyunsaturated fatty acid supplementation in early renal insufficiency in dogs. Journal of Laboratory and Clinical Medicine, v.135, p.275-286, 2000. BROWN, S.A.; BROWN, C.A.; CROWELL, W.A. et al. Beneficial effects of chronic administration of dietary Omega-3 polyunsaturated fatty acids in dogs with renal insufficiency. Journal of Laboratory and Clinical Medicine, v.131, p.447-455, 1998. BROWN, S.A.; FINCO, D.R.; CROWELL, W.A. et al. Beneficial effects of moderate phosphate restriction in partially nephrectomized dogs on a low protein diet. Kidney International, v.31, p.380, 1987. BRUM, A.M.; CHAMPION, T.; ZANATTA, R.; COSTA, M.T.; CANOLA, J.C. Utiliza??o de probi?tico e de lactulose no controle de hiperamonemia causada por desvio vascular portossist?mico cong?nito em um c?o. Ci?ncia Rural, v.37, n.2, p.572-574, 2007. BURANAKARL, C.; TRISIRIROJ, M.; PONDEENANA, S.; TUNGJITPEANPONG, T.; JARUTAKANON, P.; PENCHOME, R. Relationship between oxidative stress markers and red blood cells characteristics in renal azotemic dogs. Research in Veterinary Science, v.86, n. 2, p.309, 2009. BURTIS, C.A.; ASHWOOD, E.R. Clinical Chemistry. Philadelphia: Saunders, 1999. CAETANO, A.; DINIZ, I.; PASSOS, P.R.C.; RIBEIRO, S.S.; PESTANA, E.A. Osteodistrofia renal: a import?ncia de conhecer principais par?metros fisiol?gicos que indicam o desenvolvimento da doen?a. Revista Sapientia, v.4, p.1-7, 2012. CAMPBELL, T. W.; ELLIS, C. K. Avian and exotic animal hematology and cytology. 3. ed. Ames: Blackwell Publishing Professional, 2007. 2049p. CAMPOS, F.S.; PINHATI, F.R. O controle do c?lcio e a hipocalcemia. Cadernos UNIFOA, ed. 23, dezembro, 2013. CAN?ADO, R. D.; CHIATTONE, C. S. Anemia de doen?a cr?nica. Revista Brasileira de Hematologia e Hemoterapia, v.24, n. 2, p.127-36, 2002. CANNATA-ANDIA JB, GOMEZ ALONSO C. Vitamin D deficiency: a neglected aspect of disturbed calcium metabolism in renal failure. Nephrology Dialysis Transplantation, v.17, p.1875-1878, 2002. CARAVACA, F.; FERNANDEZ, M.A.; CUBERO J, APARICIO, A.; JIMENEZ, F. Are plasma 1,25-0dihydroxyvitamin D3 concentrations appropriate after successful kidney transplantation? Nephrology Dialysis Transplantation, v.13, p.91-93, 1998. CARDOSO, M.J.L.; COSTA, F.S.; MUNIZ, L.M.R.; MELUSSI, M.; VAL?RIO, M.A. Marcadores s?ricos do metabolismo ?sseo no hipertireoidismo felino. Ci?ncia Rural, v.38, n.5, p.1368-1374, 2008. CARNEIRO, L. F. R. Prote?nas de fase aguda em c?es com diferentes escores corporais. Disserta??o (Mestrado) ? Universidade Federal de Goi?s, Escola de Veterin?ria e Zootecnia, 2013, 100p. CARVALHO, A. B.; CUPPARI, L. Controle da hiperfosfatemia na DRC. Jornal Brasileiro de Nefrologia, S?o Paulo, v.33, Supl. 1. p.S1-S6, 2011. CARVALHO, M. B. Semiologia do sistema urin?rio. In: FEITOSA, L. Semiologia Veterin?ria: A arte do Diagn?stico, 2? ed. S?o Paulo: Roca, 2008, p.389-409. CASHMAN, K. D. Calcium intake, calcium bioavailability and bone health. British Journal of Nutrition, v.87, p.169?177, 2002. CHAICHI, P.; CHALHOUB, S.; LANGSTON, C.E.; FARRELLY, J. The use of darbepoetin to stimulate erythropoiesis in anemia of chronic kidney disease in cats: 25 cases. Journal of Veterinary Internal Medicine, v.26, p.363-369, 2012. CHALHOUB, S.; LANGSTON, C. E.; FARRELLY, J. The use of darbepoetin to stimulate erythropoiesis in anemia of chronic kidney disease in cats: 25 cases. Journal of Veterinary Internal Medicine, v.26, p.363-369, 2012. CHAMPE, P.; HARVEY, R.; FERRIER, D. Bioqu?mica Ilustrada. 4? edi??o. Editora Artmed; Porto Alegre, 2006, 533p. CHAPUY, M. C.; ARLOT, M. E.; DUBOEUF, F. Vitamin D3 and calcium to prevent hip fractures in elderly women. New England Journal of Medicine, v.327, p.1637?1642, 1992. CHEN, X.; ZHAI, X.; SHI, J.; LIU, W.W.; TAO, H.; SUN, X.; KANG, Z. Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increased hydrogen production. Digestive Diseases and Sciences, v.58, n. 6, p.1560-1568, 2013. CHESNEY, R. W.; MEHLS, O.; ANAST, C. S.; BROWN, E.; HAMMERMAN, M. R.; PORTALE, A. Renal osteodystrophy in children: the role of vitamin D, phosphorus, and paratyroid hormone. American Journal of Kidney Disease, v.7, p.275-284, 1986. CHEVILLE, N. F. Introdu??o ? patologia veterin?ria. Editora Manole, S?o Paulo, cap?tulo 2: Dist?rbios cr?ticos na homeostasia, p.23-39, 1994. CHIKAZAWA, S.; NAKAZAWA, T.; HOSHI, F.; KANAI, K.; ORINO, K.; WATANABE, K.; HIGUCHI, S. Change in serum ferritin concentration in experimentally induced anemia of chronic inflammation in dogs. Journal of Veterinary Medical Science, v.75, n. 11, p.1419-1426, 2013. CHONCHOL, M.; LIPPI, G.; MONTAGNANA, M.; MUGGEO, M.; Association of inflammation with anaemia in patients with chronic kidney disease not requiring chronic dialysis. Nephrology Dialysis Transplantation, v.23, n.9, p.2879-1883, 2008. CHUNG, J.; WESSLING-RESNICK, M. Molecular mechanisms and regulation of iron transport. Critical reviews in clinical laboratory sciences, v. 40, n. 2, p. 151-182, 2003. CILKUBA, R.; RACEK, J. Metabolic disorders in patient with chronic kidney failure. Phisiology Research, v.56, n.6, p.697-705, 2007. COELHO, A.O.; MUNDIM, A.V.; HORT?NCIO, S.M.; GUIMAR?ES, E.C.; ESPINDOLA, F. S. Influ?ncia dos fatores et?rios e sexuais nos valores de ferro s?rico e seus metab?litos em c?es da ra?a Dobermann. Veterin?ria Not?cias, v.12, n. 2, p.101, 2006. COOK, S.M.; LOTHROP, C.D. Serum erythropoietin concentration measured by radioummunoassay in normal, polycythemic and anaemic dogs and cats. Journal of Veterinary Internal Medicine, n. 8, p.18-25, 1994. COOK, J.D. Clinical evaluation of iron deficiency. Seminars in Hematology, v.19, p.6-18, 1982. COOK, J.D.; BAYNES, R.D.; SKIKNE, B.S. Iron deficiency and the measurement of iron status. Nutrition Research Reviews, v. 5, p.189-202, 1992. COWGILL, L. D. ; FRANCEY, T. New directions for the medical management of renal disease. Proceedings of the Hill?s European Symposium on Chronic Renal Disease, Rhodes, Greece. pp 40-47. 2004. COWGILL, L. D. Application of recombinant human erythropoietin in dogs and cats. In: Kirk RW, Bonagura JD, eds. Current Veterinary Therapy XI. Philadelphia, PA: WB Saunders; 1992. p.484?487. COWGILL, L. D. Pathophysiology and management of anemia in chronic progressive renal failure. Seminars in Veterinary Medicine and Surgery (Small Animal), v.7, p.175-182, 1992. COWGILL, L. D.; JAMES, K. M.; LEVY, J. K.; BROWNE, J. K.; MILLER, A.; LOBINGIER, R.T.; EGRIE, J. C. Use of recombinant human erythropoietin for management of anemia in dogs and cats with renal failure. Journal of American Veterinary Medical Association, v.212, n. 4, p.521-528, 1998. CRIVELLENTI, L. Z. Doen?a Renal Cr?nica em C?es. In.: CRIVELLENTI, L. Z.; BORIN-CRIVELLENTI, S. Casos de rotina em Medicina Veterin?ria de Pequenos Animais, 2a edi??o, Editora Medvet, Cap?tulo 11 ? Nefrologia e Urologia, p.428-436, 2015. CUMMINGS, J. H.; HILL, M. J.; BONE, E. S.; BRANCH, W. J.; JENKINS, D. J. The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in feces and urine. American Journal of Clinical Nutrition, v.32, p.2094-2101, 1979 CUNHA, D. F.; BIANCO, M. P.; LENZA, R. M.; CUNHA, S. F. C. Resposta de fase aguda e n?veis s?ricos de magn?sio em pacientes hospitalizados. Revista da Associa??o M?dica Brasileira, v.45, n. 2, p.142-146, 1999. DANTAS, A. F. M.; KOMMERS, G. D. Les?es extra-renais de uremia em 72 c?es. Ci?ncia Rural, v.27, n. 2, p.301-306, 1997. DE DOMENICO, I.; WARD, D. M.; KAPLAN, J. Hepcidin regulation: ironing out the details. The Journal of clinical investigation, v. 117, n. 7, p. 1755-1758, 2007. DE PRETER, V.; VANHOUTTE, T.; HUYS, G.; SWINGS, J.;RUTGEERTS, P.; VERBEKE, K. Effect of lactulose and Saccharomyces boulardii administration on the colonic urea-nitrogen metabolism and the bifidobacteria concentration in healthy human subjects. Alimentary Pharmacology & Therapeutics, v.23, p.963?974. 2006. DEGUCHI, T.; KUSUHARA, H.; TAKADATE, A.; ENDOU, H.; OTAGIRI, M.; SUGIYAMA, Y. Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney International, v.65, p.162-174, 2004. DEL VALLE, E.; NEGRI, A.L.; AGUIRRE, C.; FRADINGER, E.; ZANCHETTA, J.R. Prevalence of 25(OH) vitamin D insufficiency and deficiency in chronic kidney disease stage 5 patients on haemodialysis. Hemodialysis International, v.11, p.315-321, 2007. DESCAMPS-LATSCHA, B.; WITKO-SARSAT, V.; JUNGERS, P. Infection and Immunity in End-Stage Renal Disease. In Henrich WL. Principles and Practice of Dialysis, 3rd ed.by Lippincot Williams and Wilkins, 2004. DIBARTOLA, S.P. Fluid therapy in small animal practice. 3.ed. Philadelphia: Saunders, 2006. DIBARTOLA, S. P. Anormalidades de fluidos, eletr?litos e equil?brio ?cido-b?sico na cl?nica de pequenos animais. 3? edi??o, S?o Paulo-SP, Editora Roca, 2007. 680 p. DI BERNARDO, J. J.; URTIAGA, L. R.; ARR?A, E. E.; BUCHOVSKY, G.; SVIBEL, G. R. La anemia en los pacientes con Insuficiencia Renal Cr?nica em Hemodi?lisis. Comunicaciones Cient?ficas y Tecnol?gicas, Universidad Nacional Del Nordeste , 2003. DINIZ, H.F.; ROMAO, M.F.; ELIAS, R.M.; ROMAO JUNIOR, J.E. Insufici?ncia e defici?ncia de vitamina D em pacientes portadores de doen?a renal cr?nica. Brazilian Journal of Nefrology, v.34, n.1, p.58-63, 2012. DONOVAN, A.; ROY, C. N.; ANDREWS, N.C. The ins and outs of iron homeostasis. Physiology (Bethesda), v.21, p.115-123, 2006. DOS REIS L. M.; JORGETTI, V. Dist?rbios do c?lcio e do f?sforo In: ROCHA e SILVA, M.;ZATZ, R. Fisiopatologia Renal. S?o Paulo: Editora Atheneu, p.245?260, 2000. DOU, L.; JOURDE-CHICHE, N.; FAURE, V.; CERINI, C.; BERLAND, Y.; DIGNAT-GEORGE, F.; BRUNET, P. The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. Journal of Thrombosis and Haemostasis, v.5, p.1302-1308, 2007. DYCE, K.M; SACK, W.O; WENSING, C.J.G. Tratado de Anatomia Veterin?ria. Rio de Janeiro: Roca, 1990. p.110-139. ECKERSALL, P.D. Proteins, Proteomics, and the Dysproteinemias. In: KANEKO, J.J. et al. Clinical Biochemistry of Domestic Animal. 6th ed. Missouri: Saunders, 2008. p.118 ?155 EGRIE, J.C.; DWYER, E.; BROWNE, J.K.; HITZ, A.; LYKOS, M.A. Darbepoetin alfa has a longer circulation half-life and greater in vivo potency than recombinant human erythropoietin. Experimental Hematology, v.31, p.290-299, 2003. ELLIOT, J.; BARBER, P.Feline chronic renal failure: clinical findings in 80 cases diagnosed between 1992 and 1995. Journal of Small Animal Practice, v.39, p.78-85, 1998. ELLIOTT, D. A.; RIEL, D. L.; ROGERS, Q. R. Complications and outcomes associated with use of gastrostomy tubes for nutritional management of dogs with renal failure: 56 cases (1994-1999). Journal of the American Veterinary Medical Association, v.217, p.1337-1342, 2000. ELLIOTT, J.; GRAUER, G.F. Manual de nefrologia e urologia de c?es e gatos. 2a edi??o. Editora Guanabara Koogan. S?o Paulo. 2014. 334 p. ELLIOTT, J.; WATSON, A.D.J. Chronic kidney disease: staging and management. In: BONAGURA, J.D.; TWEDT, D.C. Kirk?s current veterinary therapy XIV.St. Louis: Saunders Elsevier, 2009. p.883-891. ERSLEV, A. J.; BESARAB, A. Erythropoietin in the pathogenesis and treatment of the anemia of chronic renal failure. Kidney International, v.51, p.622?630, 1997. ERSLEV, A. J. Anemia of chronic disease. In: Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U, eds. Williams Hematology. 6th ed. New York. Mc Graw Hill; p.481-487, 2001. ESCHBACH, J. W. The anemia of chronic renal failure: Pathophysiology and the effects of recombinant erythropoietin. Kidney International, v.35, p.134?148, 1989. ETIINGER, J. S.; FELDMAN, E. C. Tratado de Medicina Interna Veterin?ria: Vol 2, Insufici?ncia Renal Cr?nica, 5 ed. Rio de Janeiro: Guanabara Koogan, 2004. EWERS, B.; GASBJERG, G.; MOELGAARD, C.; FREDERIKSEN, A.M.; MARCKMANN, P.Vitamin D status in kidney transplant patients: need for intensified routine supplementation. American Journal of Clinical Nutrition, v.87, p.431-437, 2008. FAIRBANKS, V. G.; BEUTLER, E. Iron metabolism. In: BEUTLER, E.; LICHTMAN, M. A.; COLLER, B. S; KIPPS, T. J.; SELIGSOHN, U.; editors. Williams-Hematology. 6th ed. New York: Mcgraw-Hill; 2001, p. 295-304. FELDMAN, B. F.; ZINKL, J. G.; JAIN, N. C. Schalm?s veterinary hematology. 5.ed. Philadelphia: Lippincott Williams & Wilkins, 2006. 1344p. FERREIRA, A.L.A,; MATSUBARA, L.S. Radicais livres: conceitos, doen?as relacionadas, sistema de defesa e estresse oxidativo. Revista da Associa??o M?dica Brasileira, v.43, n.1, p.61-68, 1997. FIGUEIREDO, M. S. Impacto da inflama??o na regula??o do ferro e defici?ncia funcional de ferro. Revista Brasileira de Hematologia e Hemoterapia, v.32, n. 2, p.18-21, 2010. FINCO, D.R. Congenital inherited and familial renal diseases. In: OSBORNE C.A.; FINCO D.R. Canine and Feline Nephrology and Urology. William & Wilkins. Baltimore. 1995. p.471-483 FINCO, D. R. Kidney function. In: Kaneko JK, Harwey JW, Bruss ML. Clinical biochemistry of domestic animals. 5th ed. San Diego: Academic Press; 1997. FOSTER, J. D. Update on Mineral and Bone Disorders in Chronic Kidney Disease. Veterinary Clinics of North America: Small Animal Practice, 2016, 19p. FOURNIER A, FARDELLONE P, ACHARD JM, Importance of vitamin D repletion in uremia. Nephrology Dialisys and Transplantation, v.14, p.819-823. 1999 FREUNDLICH M, QUIROZ Y, ZHANG Z, et al. Suppression of renin-angiotensin gene expression in the kidney by paracalcitol. Kidney International, v.74, p.1394-1402, 2008. GABRIEL, I. C.; NISHIDA, S. K.; KIRSZTAJN, G. M. Cistatina C s?rica: uma alternativa pr?tica para avalia??o de fun??o renal? Jornal Brasileiro de Nefrologia, v.33, n. 2, p.261-267, 2011. GARCIA-NAVARRO, C. E. K.; PACHALY, J. R. Manual de hematologia veterin?ria. Livraria Varela, S?o Paulo, 1994, 169 p. GENUTH, S. M. Regula??o end?crina do metabolismo do c?lcio e do fosfato. In: BERNE, R. M.; LEVY, M. N. Fisiologia. Rio de Janeiro: Guanabara - Koogan, 2000. cap.48, p.800 ? 821. GIBSON, S. A.; MCFARLAN, C.; HAY, S.; MACFARLANE, G. T. Significance of microflora in proteolysis in the colon. Applied and Environmental Microbiology, v. 55, p.679-683, 1989. GIGLIO, R.F.; FERRIGNO, C.R.A.; STERMAN, F.A.; PINTO, A.C.B.F.; BALIEIRO, J.C.C.; ABROSIO, C.E.; LIMA, A.R.; GRANDO, A.P.; Estudo longitudinal da densidade mineral ?ssea de c?es Golden Retriever h?gidos, portadores e afetados pela distrofia muscular. Brazilian Journal of veterinary Research and animal Science, v.46, n.5, p.347-354, 2009. GONZALES EA, SACHDEVA A, OLIVER DA, MARTIN, J.K. Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study. American Journal of Nephrology, v.24, n.5, p.503-510, 2004. GONZ?LEZ, F. H. D.; SILVA, S. C. Introdu??o ? bioqu?mica cl?nica veterin?ria. Porto Alegre: Universidade Federal do Rio Grande do Sul; 2003. GOODMAN, W.G.; COBURN, J.W.; SLATOPOLSKY, E.; SALUSKY, I.B. Renal osteodystrophy in adults and children. In: FAVUS, M,J, (ed). Primer on the metabolic bone disease and disorders of mineral metabolism. 4th ed. Philadelphia: Lippincott Williams & Williams; 1999. p.347-363. GRACITELLI, M. E. C.; VIDORIS, A. A. C.; LUBA, R.; LAZARETTI-CASTRO, M. Paratorm?nio e Osteoporose: Encontrando o Fio da Meada. Bases Fisiol?gicas para Utiliza??o do PTH no Tratamento da Osteoporose. Arquivos Brasileiros de Endocrinologia e Metabologia, v.46, p.215?220, 2002. GRAUER, G. F.; GRECO, D.; GRETZY, D. et al. Effects of enalapril treatment versus placebo as a treatment for canine idiophatic glomerulonephritis. Journal of Veterinary Internal Medicine, v.14, p.526-533, 2000. GRAUER, G. F.; THOMAS, C. B.; EICKER, S. W. Estimation of quantitative proteinuria in the dog, using the urine protein-creatinine ratio from a random, voided sample. American Journal of Veterinary Research, v.46, p.2116-2119, 1985. GREENE, C.E. Infectious Diseases of The Dog and Cat. Athens: Saunders, 2006. 934p. GREIVE, K. A.; BALAZS, N. D.; COMPER, W.D. Protein fragments in urine have been considerably underestimated by various protein assays. Clinical chemistry, v.47, p.1717-1719, 2001. GRIFFITHS, E. Iron in biological systems. Iron and infection. Wiley, Chichester, United Kingdom, p. 1-26, 1999. GROTTO, H. Z. W. Anaemia of cancer: an overview of mechanisms involved in its pathogenesis. Medical oncology, v. 25, n. 1, p. 12-21, 2008. GROTTO, H.Z.W. Metabolismo do ferro: uma revis?o sobre os principais mecanismos envolvidos em sua homeostase. Revista Brasileira de Hematologia e Hemoterapia, v.30, n. 5, p.390-397, 2008. GR?DTNER, V.S.; WEINGRILL, P.; FERNANDES, A. L. Aspectos da Absor??o no Metabolismo do C?lcio e Vitamina D. Revista Brasileira de Reumatologia, v.37, p.143?151, 1997. GUNN-MOORE, D.; et al. Influence of proteinuria on survival time in cats with chronic renal insufficiency. Journal of Veterinary Internal Medicine, v.17, n. 405A, 2003. GUTIERREZ O, ISAKOVA T, RHEE E, et al. Fibroblast growth factor-23 mitigates hyperphosphatemia but accelerates calcitriol deficiency in chronic kidney disease. Journal of the American Society of Nephrology, v.16, p.2205-2215, 2005. GUYTON, A. C.; HALL, J. E. Tratado de Fisiologia M?dica. 11? ed. Rio de Janeiro: Elsevier, 2006. GUYTON, A.C.; HALL, J. E. Tratado de Fisiologia M?dica. 12? edi??o. Editora Elsevier. Rio de Janeiro. 2011. HABIBZADEH, A.; HANSEL, D.E.; DINTZIS, R.Z. Fundamentos da Patologia. Rio de Janeiro: Guanabara Koogan. 2007. 937p. HARRIS D, COLLINS J, DISNEY A, et al. Darbepoetin alfa: A new erythropoietic drug for the treatment of renal anaemia. Nephrology, v.7; p.S173-S180, 2002. HARRISON, T.R.; FAUCI, A.S. Princ?pios de Medicina Interna. M?xico, D.F.: McGraw-Hill Interamericana, 17? ed., Vol. 2, 2009. p.1913-1619. HEAF, J.; TVEDEGAARD, E.; KANSTRUP, I.L.; FOGH-ANDERSEN, N. Bone loss after renal transplantation: role of hyperparathyroidism, acidosis, cyclosporine, and systemic disease. Clinical Transplantation, v.14, p.457-63, 2000. HEANEY, R. P.; DOWELL, M. S.; HALE, C. A.; BENDICH, A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. Journal of the American College of Nutrition, v.22, p.142?146, 2002. HEIJNEN, A. M. P.; BRINK, E. J.; LEMMENS, A. G.; BEYNEN, A. C. Ileal pH and apparent absorption of magnesium in rats fed on diets containing either lactose or lactulose. British Journal of Nutrition, v.70, n. 3, p.747-756, 1993. HENDRIX, P.K.; RAFFE, M.R. In: BOJRAB, M.J. Mecanismos da mol?stia na cirurgia dos pequenos animais. 2.ed. S?o Paulo: Manole, p.26-38, 1996. HENNEBERG, R.; CORREA, J. R. A.; KOPP, R. L.; SILVA, P.H. Ferrocin?tica e ?ndices hematol?gicos no diagn?stico laboratorial da anemia ferropriva - revis?o bibliogr?fica. NewsLab, ed. 107, p.134-144, 2011. HOFFBRAND, A.V.; PETTIT, F.E.; MOSS, P.A. H. Essential Haematology. 5th ed. Oxford (UK): Blackwell Publishing; c2006. Chapter 3,Hypochromic anaemias and iron overload; p.28-43 HOFFMANN, L. P.; POLLETTI, C.; ROEHRIG, K. S.; AZIZ, M. M.; KUNTZ, A. K.; DALL?CORTIVO, G.; SOUZA, N. M. A.; SANTOS, M. C. S. Avalia??o dos ?ndices Hematim?tricos emitidos pelos contadores hematol?gicos Pentra 120 Range e Sysmex XT-2000i. Revista Brasileira de An?lises Cl?nicas, v.39, n. 1, p.25-28, 2007. HOLICK, M.F. Vitamin D deficiency. New England Journal of Medicine, v.14, n.1. p.357:366, 2007. HOLZ, P.H.; MIDDLETON, D. R. Prospective Study. Medical Surgery, v.15, p.4-6, 2005. INTERNATIONAL RENAL INTEREST SOCIETY. Staging of Chronic Kidney Disease. 2009. Dispon?vel em: http://www.iriskidney.com/guidelines INTERNATIONAL RENAL INTEREST SOCIETY. Staging of Chronic Kidney Disease. 2013. Dispon?vel em: http://www.iriskidney.com/guidelines INTERNATIONAL RENAL INTEREST SOCIETY. Staging of Chronic Kidney Disease. 2016. Dispon?vel em: http://www.iriskidney.com/guidelines ISHIMURA, E.; NISHIZAWA, Y.; INABA, M.; Serum levels of 1,25-dihydroxyvitamin D, 24-25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. Kidney International, v.55, p.1019-1027, 1999. JACKSON, R. D.; LACROIX, A. Z.; GASS, M. Calcium plus vitamin D supplementation and the risk of fractures. New England Journal of Medicine, v.354, p.669?683, 2006. JACOB, F.; POLZIN, D.J.; OSBORNE, C.A.; et al. Association between initial systemic blood pressure and risk of developing a uremic crisis or of dying in dogs with chronic renal failure. Journal of the American Veterinary Medical Association, v.222, p.322-329, 2003. JACOB, F.; POLZIN, D.J.; OSBORNE, C.A.; et al. Clinical evaluation of dietary modification for treatment of spontaneous chronic renal failure in dogs. Journal of the American Veterinary Medical Association, v.220, n. 8, p.1163-1170, 2002. JAIN, N.C. Essentials of Veterinary Hematology. Philadelphia: Lea & Febiger, 1993. 417p. JAIN N.C. Blood loss or hemorrhagic anemias. In: FELDMAN, B.F. et al. Schalm?s veterinary hematology. 5.ed. Baltimore: Lippincott Williams & Wilkins, 2000. p.580-585. JING, S. B.; LI, L.; JI, D.; TAKIGUCHI, Y.; YAMAGUCHI, T. Effect of chitosan on renal function in patients with chronic renal failure. Journal of Pharmacy and Pharmacology, v.49, n. 7, p.721?723, 1997. JUNQUEIRA, L.C.; CARNEIRO, J. Histologia b?sica. Cap?tulo 19 ? Aparelho Urin?rio. 10a edi??o. Editora Guanabara Koogan. p.371-386. 2004. KALANTAR-ZADEH, K.; REGIDOR, D. L.; MCALLISTER, C. J.; MICHAEL, B.; WARNOCK, D. G. Time-dependent associations between iron and mortality in hemodialysis patients. Journal of the American Society of Nephrology, v.16, n. 10, p.3070-3080, 2005. KANEKO, J. J.; HARVEY, J. W.; BRUSS, M. L. Clinical biochemistry of domestic animals. 7. ed. San Diego: Academic Press, 2008. 912 p. KAWANO, Y. Role of blood pressure monitoring in non-pharmacological management of hypertension. Blood Pressure Monitoring, v.7, n. 1, p.51-54, 2002. KERL, M. E.; LANGSTON, C. E. Treatment of anemia in renal failure. In: BONAGURA, J. D.; TWEDT, D. C. Kirk's current veterinary therapy XIV, Saunders, Elsevier, Philadelphia, 2009, 914p. KERR, M.G. The plasma proteins. In: KERR, M. G. Veterinary Laboratory Medicine. 2nd ed. Oxford: Blackwell Science, 2002. p.73 ? 80. KHOSHBATEN, M.; KIDDER, A.; CHEW, D. Treatment options for hyperphosphatemia in feline CKD What?s out there? Journal of feline medicine and surgery, v.11, p.913-924, 2009. KLAHR, S.; SLATOPOLSKY, E. Toxicity of parathyroid hormone in uremia. Annual Review of Medicine, v.37, p.71-78, 1986. KNUTSON, M.; WESSLING-RESNICK, M. Iron metabolism in the reticuloendothelial system. Critical reviews in biochemistry and molecular biology, v. 38, n. 1, p. 61-88, 2003. KOVESDY, C.P. Rate of kidney function decline associates with increased risk of death. Journal of the American Society of Nephrology, v.21, n.11, p.1814-1816, 2010. KRAUSE, A.; NEITZ, S.; M?GERT, H. J.; SCHULZ, A.; FORSSMANN, W. G.; SCHULZ-KNAPPE, P.; ADERMANN, K. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS letters, v. 480, n. 2-3, p. 147-150, 2000. KRISHNAMURTHY, P.; XIE, T.; SCHUETZ, J. D. The role of transporters in cellular heme and porphyrin homeostasis. Pharmacological Therapy, v.114, n. 3, p.345-358, 2007. KRUEGER, J.M.; OSBORNE, C.A. Canine and feline hypercalcemic nephropathy. In: OSBORNE, C.A.; FINCO, D.R. Canine and feline nephrology and urology. Philadelphia: Willians & Wilkins, 1995. p.416-440. KRUEGER, J.M.; OSBORNE, C.A.; NACHRE |
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