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Previous issue date: 2007-03-05 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The aim of the present study was to analyze the interference of the administration of
piperine in broiler chickens with prolonged aflatoxins intoxication. The experiment was
accomplished in two phases: (i) the chickens were separate in four groups test (n=15
broilers / I group), that received different piperine concentrations (1.12, 2.25 and 4.5mg/kg
orally/14 days), and a control group, that was only inoculated with the vehicle; (ii) chickens
were separate in 3 groups (n=15 broilers/group), a group that received only piperine (2.25
mg/kg), a group that received aflatoxins only (2.0 mg/kg) and another group that received
an association of piperine (2.25 mg/kg) and aflatoxins (2.0 mg/kg), all orally / 14 days. At
the end of the experiment, the chickens were slaughted and productivity indexes,
hematological parameters and histopathological parameters of every digesting tract were
evaluated. The results obtained in the first phase showed that the piperine, in the employed
doses, didn't interfere in the productivity indexes nor in the result of the values of
hematocrit, hemoglobin concentration, fibrinogen and erythrocyte counts, except for the
highest doses of piperine, which were capable to promote an increase in the total counting
of the white blood cells. The dose of 2.25 piperine mg/kg was not toxic or had and the
histopathological lesions observed were dose-dependent. In the second phase of the
experiment, it was observed that the productivity indexes in the group that received the
association piperine and aflatoxins obtained better performing comparatively with those
that just received aflatoxins. The piperine in the concentration of 2.25 mg/kg reduced in a
significant way the immunosuppresor activity and the histopathological lesions caused by
the aflatoxins. It can be suggested that piperine interferes in a positive way, reducing the
toxic effects of the aflatoxins intoxication in broiler chickens. / Este trabalho teve como objetivo analisar a interfer?ncia da administra??o da piperina em
frangos de corte com intoxica??o prolongada por aflatoxinas. O experimento foi realizado
em duas fases: (i) os frangos foram separados em quatro grupos teste (n=15 aves/ grupo),
que receberam diferentes concentra??es de piperina (1,12; 2,25 e 4,5mg/kg por via oral/14
dias), e um grupo controle, que foi inoculado apenas com o ve?culo; (ii) os frangos foram
separados em 3 grupos (n=15 aves/grupo), um grupo que recebeu apenas piperina (2,25
mg/kg), um grupo que recebeu apenas aflatoxinas (2,0 mg/kg) e outro grupo recebeu
piperina (2,25 mg/kg) em associa??o com aflatoxinas (2,0 mg/kg), todos por via oral/ 14
dias. Ao final do experimento, os frangos foram abatidos e avaliados quanto aos ?ndices de
produtividade, par?metros hematol?gicos e par?metros histopatol?gicos de todo trato
digest?rio. Os resultados obtidos na primeira fase mostraram que a piperina, nas doses
empregadas, n?o interferiu nos ?ndices de produtividade ou nos valores de hemat?crito,
hemoglobina, fibrinog?nio e n?mero de hem?cias, com exce??o das doses mais elevadas de
piperina, as quais foram capazes de promover um aumento na contagem total de leuc?citos.
A dose de 2,25 mg/kg de piperina n?o foi t?xica ou imunossupressora e as les?es
histopatol?gicas observadas foram dose dependente. Na segunda fase do experimento,
observou-se que de acordo com os ?ndices de produtividade, o grupo que recebeu piperina
em associa??o com aflatoxinas obteve melhor desempenho comparativamente com aqueles
que receberam apenas aflatoxinas. A piperina na concentra??o de 2,25 mg/kg reduziu de
forma significativa ? imunossupress?o e as les?es histopatol?gicas causada pelas
aflatoxinas. Desta forma, pode-se sugerir que a piperina interfere de forma positiva na
intoxica??o de frangos de corte por aflatoxinas, diminuindo seus efeitos t?xicos.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:tede/857 |
| Date | 05 March 2007 |
| Creators | Cardoso, Ver?nica da Silva |
| Contributors | Direito, Gl?ria Maria, Danelli, Maria das Gracas Miranda |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Microbiologia Veterin?ria, UFRRJ, Brasil, Microbiologia Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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