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Previous issue date: 2005-03-07 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / BHV-1, the agent of IBR, IPV and IPB, is spread among cattle and buffalo herds, bringing
sanitary and economic losses to the livestock industry in Brazil and the world. These diseases
can present clinical signs that fake Food-and-Mouth Disease and other vesicular diseases, and
differential diagnosis in referenced laboratories is required. The high incidence is a hazardous
risk for livestock, as the infection has an insidious character, with a subclinical form,
generally unnoticed by the people involved with the cattle maintenance. As the control of the
infection is required but there are few reasonable alternatives for the situation within Brazilian
herds, we need new strategies for the control of the disease, which will be of major concern
for fighting the infection in the world. Vaccines can t protect from infection and confuse
diagnostics. Using attenuated vaccines a latent infection can be started. The disease will be
the next sanitary barrier for the international trade of animals and products in the European
Union. BHV-1 has been eradicated from Austria, Denmark, Finland, Sweden and Switzerland
and control programs have started in some other countries. In the present research, we
appreciated clinical and epidemiological aspects of the disease, evaluating the BHV-1
presence in Rio de Janeiro state. We have proposed a new method for the diagnostics of
infected breeding cows, using the neutralization test in microplates with MDBK monolayers.
We have evaluated the efficiency of passive immunization after colostrum ingestion. The
effect of Kalanchoe brasiliensis extracts against BHV-1 in MDBK cells was evaluated. The
control of the infection with homeopathic and phytotherapy therapeutics is proposed and the
publications about BHV-1 vaccination were reviewed. Measures for the control of the
infection in cattle herds from Rio de Janeiro State are suggested. / O BHV-1 ? conhecido genericamente como o agente etiol?gico da IBR, da IPV e da IPB, e
est? disseminado em rebanhos bovinos e bubalinos do Brasil e do mundo, causando preju?zos
econ?micos e sanit?rios ? atividade pecu?ria. Ainda pode apresentar sintomatologia
semelhante ? da Febre Aftosa e outras enfermidades vesiculares, de forma que o diagn?stico
diferencial de laborat?rio ? exigido. A alta preval?ncia de animais positivos representa um
s?rio risco para a atividade pecu?ria, considerando-se a recidividade da infec??o, que
apresenta uma forma subcl?nica, facilmente despercebida pelos envolvidos com a
bovinocultura. Sendo objeto de controle em todo o mundo, mas com poucas alternativas
vi?veis na situa??o atual do rebanho brasileiro, urge a defini??o de novas estrat?gias de
controle da infec??o. A vacina??o n?o protege da infec??o, prejudica a identifica??o dos
animais portadores e, no caso de vacinas atenuadas, pode estabelecer infec??o latente. A
enfermidade ser? a pr?xima barreira sanit?ria ao com?rcio internacional de animais vivos e
seus produtos na Uni?o Europ?ia e j? foi erradicada da ?ustria, Dinamarca, Finl?ndia, Su??a e
Su?cia, e programas de controle foram iniciados em outros pa?ses europeus. Neste trabalho
abordamos aspectos cl?nicos e epidemiol?gicos da doen?a, avaliando a ocorr?ncia da infec??o
pelo BHV-1 no Estado do Rio de Janeiro. Tamb?m propomos uma nova metodologia para o
diagn?stico de matrizes infectadas pelo BHV-1, usando a t?cnica de neutraliza??o em
microplacas com c?lulas MDBK cultivadas em monocamadas; avaliamos a efici?ncia da
imuniza??o passiva, a partir da ingest?o do colostro; apresentamos propostas de controle da
doen?a com tratamentos homeop?ticos e fitoter?picos; avaliamos o efeito do extrato de
Kalanchoe brasiliensis frente ao BHV-1 in vitro; revisamos a literatura referente ? vacina??o
contra a doen?a e sugerimos medidas para o controle da doen?a em rebanhos do Estado do
Rio de Janeiro.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:tede/888 |
| Date | 07 March 2005 |
| Creators | Schiavo, Paula Amorim |
| Contributors | Andrade, Cla?dio de Moraes |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Curso de P?s-Gradua??o em Medicina Veterin?ria, UFRRJ, Brasil, Cl?nica e Cirurgia Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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